Gene

kcnh1a

ID
ZDB-GENE-061226-1
Name
potassium voltage-gated channel, subfamily H (eag-related), member 1a
Symbol
kcnh1a Nomenclature History
Previous Names
  • kcnh1
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Exhibits voltage-gated potassium channel activity. Involved in hindbrain formation and somitogenesis. Predicted to localize to integral component of plasma membrane. Is expressed in heart; nervous system; pleuroperitoneal region; and trunk. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human KCNH1 (potassium voltage-gated channel subfamily H member 1).
Genome Resources
Note
None
Expression
All Expression Data
1 figure from Stengel et al., 2012
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Stengel et al., 2012
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With kcnh1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Temple-Baraitser syndrome 611816
Zimmermann-Laband syndrome 1 135500
Associated With kcnh1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000014 PAS domain
Domain IPR000595 Cyclic nucleotide-binding domain
Domain IPR000700 PAS-associated, C-terminal
Domain IPR005821 Ion transport domain
Family IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
Family IPR003949 Potassium channel, voltage-dependent, EAG
Family IPR030170 Potassium voltage-gated channel subfamily H member 1
Homologous_superfamily IPR014710 RmlC-like jelly roll fold
Homologous_superfamily IPR018490 Cyclic nucleotide-binding-like
Homologous_superfamily IPR027359 Voltage-dependent channel domain superfamily
Homologous_superfamily IPR035965 PAS domain superfamily
Repeat IPR001610 PAC motif
Domain Details Per Protein
Protein Length Cyclic nucleotide-binding domain Cyclic nucleotide-binding-like Ion transport domain PAC motif PAS-associated, C-terminal PAS domain PAS domain superfamily Potassium channel, voltage-dependent, EAG Potassium channel, voltage-dependent, EAG/ELK/ERG Potassium voltage-gated channel subfamily H member 1 RmlC-like jelly roll fold Voltage-dependent channel domain superfamily
UniProtKB:Q108P3 959
UniProtKB:F1RBF8 959
UniProtKB:B3DHL9 959
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations