Gene

atp7b

ID
ZDB-GENE-061220-5
Name
ATPase copper transporting beta
Symbol
atp7b Nomenclature History
Previous Names
  • si:dkey-276l13.3 (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have copper transmembrane transporter activity, phosphorylative mechanism. Predicted to be involved in cellular copper ion homeostasis and copper ion export. Predicted to localize to perinuclear region of cytoplasm and trans-Golgi network. Is expressed in head and liver. Human ortholog(s) of this gene implicated in Wilson disease. Orthologous to human ATP7B (ATPase copper transporting beta).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With atp7b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Wilson disease Alliance Wilson disease 277900
Associated With atp7b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017969 Heavy-metal-associated, conserved site
Domain IPR006121 Heavy metal-associated domain, HMA
Domain IPR006122 Heavy metal-associated domain, copper ion-binding
Domain IPR044492 P-type ATPase, haloacid dehalogenase domain
Family IPR001757 P-type ATPase
Family IPR027256 P-type ATPase, subfamily IB
Homologous_superfamily IPR008250 P-type ATPase, A domain superfamily
Homologous_superfamily IPR023214 HAD superfamily
Homologous_superfamily IPR023298 P-type ATPase, transmembrane domain superfamily
Homologous_superfamily IPR023299 P-type ATPase, cytoplasmic domain N
Homologous_superfamily IPR036163 Heavy metal-associated domain superfamily
Homologous_superfamily IPR036412 HAD-like superfamily
PTM IPR018303 P-type ATPase, phosphorylation site
Domain Details Per Protein
Protein Length HAD-like superfamily HAD superfamily Heavy-metal-associated, conserved site Heavy metal-associated domain, copper ion-binding Heavy metal-associated domain, HMA Heavy metal-associated domain superfamily P-type ATPase P-type ATPase, A domain superfamily P-type ATPase, cytoplasmic domain N P-type ATPase, haloacid dehalogenase domain P-type ATPase, phosphorylation site P-type ATPase, subfamily IB P-type ATPase, transmembrane domain superfamily
UniProtKB:A0A8M3B381 1332
UniProtKB:A0A8N7T720 1364
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA atp7b-201 (1) Havana 4092 nt
mRNA atp7b-202 (1) Ensembl 3678 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations