ZFIN ID: ZDB-GENE-061220-3
Gene Name: pyruvate dehydrogenase kinase, isozyme 3a
Gene Symbol: pdk3a    Nomenclature History

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Previous Name: pdk3

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine kinase activity. Predicted to be involved in glucose homeostasis and negative regulation of pyruvate dehydrogenase activity. Predicted to localize to mitochondrion. Is expressed in brain. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked dominant 6. Orthologous to human PDK3 (pyruvate dehydrogenase kinase 3).
Genome Resources: Alliance (1),  Gene:560068 (1),  Ensembl(GRCz11):ENSDARG00000014527 (2)
GENE EXPRESSION
All Expression Data: Fig. 6 from Zhuo et al., 2012
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH pdk3a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Charcot-Marie-Tooth disease X-linked dominant 6 Alliance ?Charcot-Marie-Tooth disease, X-linked dominant, 6 300905
DISEASE ASSOCIATED WITH pdk3a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process phosphorylation (more)
Cellular Component mitochondrial matrix (more)
Molecular Function ATP binding (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA pdk3a-201 (1)    Ensembl 1525
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM pdk3a No data available
MARKER RELATIONSHIPS
pdk3a Contained in: [BAC] DKEY-227M20 (order this)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_005162757 (1) 2169 nt
Genomic GenBank:CR759925 (1) 38062 nt
Select Tool
Polypeptide UniProtKB:A0A2R8QMA3 (1) 405 aa
Sequence Information (all 9)
ORTHOLOGY for pdk3a ( Chr: 24 )
CITATIONS (22)