Gene

adnpa

ID
ZDB-GENE-061215-112
Name
activity-dependent neuroprotector homeobox a
Symbol
adnpa Nomenclature History
Previous Names
  • adnp1a (1)
  • wu:fi35b06
  • zgc:154063
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Enables beta-catenin binding activity. Involved in regulation of neurogenesis. Acts upstream of or within Wnt signaling pathway involved in dorsal/ventral axis specification and erythrocyte maturation. Is active in cytoplasm. Is expressed in eye; forebrain; midbrain; and midbrain hindbrain boundary. Human ortholog(s) of this gene implicated in Helsmoortel-Van Der Aa Syndrome. Orthologous to human ADNP (activity dependent neuroprotector homeobox).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Dresner et al., 2012
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With adnpa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Helsmoortel-Van Der Aa Syndrome Alliance Helsmoortel-van der Aa syndrome 615873
Associated With adnpa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001356 Homeobox domain
Domain IPR013087 Zinc finger C2H2-type
Domain IPR045762 ADNP, zinc finger domain
Family IPR038861 Activity-dependent neuroprotector homeobox protein
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Activity-dependent neuroprotector homeobox protein ADNP, zinc finger domain Homeobox domain Homeobox-like domain superfamily Zinc finger C2H2-type
UniProtKB:A1A5I2 969
UniProtKB:F1QLG5 969
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations