ZFIN ID: ZDB-GENE-061207-74
Gene Name: dickkopf WNT signaling pathway inhibitor 3b
Gene Symbol: dkk3b    Nomenclature History

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Previous Names: dkk3, si:dkey-80c24.6

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have co-receptor binding activity and receptor antagonist activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to localize to extracellular space. Is expressed in posterior pancreatic bud. Orthologous to human DKK3 (dickkopf WNT signaling pathway inhibitor 3).
Genome Resources: Alliance (1),  Gene:100038765 (1),  Ensembl(GRCz11):ENSDARG00000070683 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1295 Point Mutation Unknown Premature Stop ENU
sa24628 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dkk3b N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH dkk3b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH dkk3b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process multicellular organism development (more)
    Cellular Component extracellular region (more)
    Molecular Function co-receptor binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dkk3b-201 (1)    Ensembl 1118
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dkk3b No data available
    MARKER RELATIONSHIPS
    dkk3b Contained in: [BAC] DKEY-80C24 (1) (order this)
    dkk3b Encodes: [cDNA] MGC:162332 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001089545 (1) 1143 nt
    Genomic GenBank:CR759887 (1) 215263 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A2CEU2 (1) 283 aa
    Sequence Information (all 9)
    ORTHOLOGY for dkk3b ( Chr: 25 )
    CITATIONS (32)