Gene

grin2bb

ID
ZDB-GENE-061207-27
Name
glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b
Symbol
grin2bb Nomenclature History
Previous Names
  • grin2b
  • GRIN2Bb (1)
  • NR2B.2 (1)
  • si:ch211-243a20.1
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have NMDA glutamate receptor activity and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in excitatory postsynaptic potential; glutamatergic synaptic transmission; and long-term synaptic potentiation. Predicted to localize to NMDA selective glutamate receptor complex and postsynaptic density membrane. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; autosomal dominant non-syndromic intellectual disability 6; bipolar disorder; early infantile epileptic encephalopathy 27; and neurodegenerative disease (multiple). Orthologous to human GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With grin2bb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant intellectual developmental disorder 6 Alliance Intellectual developmental disorder, autosomal dominant 6, with or without seizures 613970
developmental and epileptic encephalopathy 27 Alliance Developmental and epileptic encephalopathy 27 616139
Associated With grin2bb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001320 Ionotropic glutamate receptor
Domain IPR001828 Receptor, ligand binding region
Domain IPR018884 Glutamate [NMDA] receptor, epsilon subunit, C-terminal
Domain IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
Family IPR001508 Ionotropic glutamate receptor, metazoa
Homologous_superfamily IPR028082 Periplasmic binding protein-like I
Domain Details Per Protein
Protein Length Glutamate [NMDA] receptor, epsilon subunit, C-terminal Ionotropic glutamate receptor Ionotropic glutamate receptor, L-glutamate and glycine-binding domain Ionotropic glutamate receptor, metazoa Periplasmic binding protein-like I Receptor, ligand binding region
UniProtKB:A2BH14 1770
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations