ZFIN ID: ZDB-GENE-061207-27
Gene Name: glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b
Gene Symbol: grin2bb    Nomenclature History

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Previous Names: grin2b, GRIN2Bb (1), NR2B.2 (1), si:ch211-243a20.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have NMDA glutamate receptor activity and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in excitatory postsynaptic potential; glutamatergic synaptic transmission; and long-term synaptic potentiation. Predicted to localize to NMDA selective glutamate receptor complex and postsynaptic density membrane. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; autosomal dominant non-syndromic intellectual disability 6; bipolar disorder; early infantile epileptic encephalopathy 27; and neurodegenerative disease (multiple). Orthologous to human GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B).
Genome Resources: Alliance (1),  Gene:559976 (1),  Ensembl(GRCz11):ENSDARG00000030376 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Juvenile:Days 45-89 (45d-90d, 14 mm, 12 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la013686Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la021225Tg Transgenic Insertion Unknown Unknown DNA
    la021226Tg Transgenic Insertion Unknown Unknown DNA
    sa9856 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12697 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18703 Point Mutation Unknown Premature Stop ENU
    sa19556 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH grin2bb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant non-syndromic intellectual disability 6 Alliance Mental retardation, autosomal dominant 6 613970
    early infantile epileptic encephalopathy 27 Alliance Epileptic encephalopathy, early infantile, 27 616139
    DISEASE ASSOCIATED WITH grin2bb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ion transport (more)
    Cellular Component cell junction (more)
    Molecular Function ion channel activity (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA grin2bb-201 (1)    Ensembl 9345
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM grin2bb No data available
    MARKER RELATIONSHIPS
    grin2bb Contained in: [BAC] CH211-132L20 (1), CH211-243A20 (1), DKEY-48A12 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001128337 (1) 5313 nt
    Genomic GenBank:BX901927 (1) 152042 nt
    Select Tool
    Polypeptide UniProtKB:A2BH14 (1) 1770 aa
    Sequence Information (all 17)
    ORTHOLOGY for grin2bb ( Chr: 1 )
    CITATIONS (29)