ZFIN ID: ZDB-GENE-061204-2
Gene Name: RAR-related orphan receptor B
Gene Symbol: rorb    Nomenclature History

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Previous Names: nr1f2 (1), NR1F2 (1), sb:eu943

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have several functions, including nuclear receptor activity; steroid hormone receptor activity; and zinc ion binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in idiopathic generalized epilepsy 15. Is expressed in alar plate midbrain region; immature eye; and nervous system. Orthologous to human RORB (RAR related orphan receptor B).
Genome Resources: Alliance (1),  Gene:567943 (1),  Ensembl(GRCz11):ENSDARG00000033498 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH rorb HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
idiopathic generalized epilepsy 15 Alliance {Epilepsy, idiopathic generalized, susceptibility to, 15} 618357
DISEASE ASSOCIATED WITH rorb VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process regulation of transcription, DNA-templated (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Domain IPR001628 Zinc finger, nuclear hormone receptor-type
Family IPR001723 Nuclear hormone receptor
Family IPR003079 Nuclear receptor ROR
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA rorb-201 (1)    Ensembl 1594
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM rorb No data available
MARKER RELATIONSHIPS
rorb Contained in: [BAC] DKEY-182N3 (1) (order this), DKEYP-40D11
rorb Encodes: [EST] dq017626 (1), eu943 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001082856 (1) 1401 nt
Genomic GenBank:BX537293 (1) 134768 nt
Select Tool
Polypeptide UniProtKB:A3R3J9 (1) 466 aa
Sequence Information (all 20)
ORTHOLOGY for rorb ( Chr: 5 )
CITATIONS (30)