ZFIN ID: ZDB-GENE-061130-2
Gene Name: transmembrane immune signaling adaptor TYROBP
Gene Symbol: tyrobp    Nomenclature History

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Previous Name: dap12 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have signaling receptor binding activity. Involved in phosphatidylinositol 3-kinase signaling. Predicted to localize to cell surface. Is expressed in liver; lymphocyte; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Nasu-Hakola disease. Orthologous to human TYROBP (transmembrane immune signaling adaptor TYROBP).
Genome Resources: Alliance (1),  Gene:100101461 (1),  Ensembl(GRCz11):ENSDARG00000094894 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH tyrobp HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Nasu-Hakola disease Alliance Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 221770
DISEASE ASSOCIATED WITH tyrobp VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process phosphatidylinositol 3-kinase signaling (more)
Cellular Component integral component of membrane (more)
Molecular Function protein binding (more)
GO Terms (all 19)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA tyrobp-201 (1)    Ensembl 796
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM tyrobp No data available
MARKER RELATIONSHIPS
tyrobp Contained in: [BAC] DKEY-29H14 (order this), DKEY-104N21 (order this)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001100103 (1) 798 nt
Genomic GenBank:BX323874 256605 nt Blast at MegaBLAST
Polypeptide UniProtKB:A6Y956 (1) 115 aa
Sequence Information (all 12)
ORTHOLOGY for tyrobp ( Chr: 16 )
CITATIONS (11)