ZFIN Gene: aldh1a3

ZFIN ID: ZDB-GENE-061128-2

ZFIN ID: ZDB-GENE-061128-2

Gene Name:

aldehyde dehydrogenase 1 family, member A3

Gene Symbol:

aldh1a3

Sequence Ontology ID :

SO:0000704

Previous Name:

Raldh3 (1)

Location:

Chr: 7 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Predicted to have aldehyde dehydrogenase (NAD) activity; predicted to be involved in oxidation-reduction process; orthologous to human ALDH1A3 (aldehyde dehydrogenase 1 family member A3).

GENE EXPRESSION
All Expression Data:	20 figures from 16 publications
Wild-type Stages, Structures:	Cleavage:64-cell (2.0h-2.25h) to Adult (90d-730d, breeding adult)
	anterior crista anterior macula brain eye gill hypophysis immature eye inner ear kidney lateral crista muscle optic cup ventral region optic cup otic vesicle antero-ventral region otic vesicle ovary posterior crista presumptive neural retina retina postero-ventral region retina ventral region retina retinal neural layer ventral side semicircular canal spleen swim bladder testis whole organism

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa118	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa15721	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa34007	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Targeting reagents:

MO1-aldh1a3 (1)

PHENOTYPE

Data:	8 figures from 2 publications
Observed in:	eye forebrain hindbrain midbrain hindbrain boundary retina rhombomere 1

DISEASE ASSOCIATED WITH aldh1a3 HUMAN ORTHOLOG

Disease Ontology Term	OMIM Term	OMIM Phenotype ID
isolated microphthalmia 8	Microphthalmia, isolated 8	615113

DISEASE ASSOCIATED WITH aldh1a3 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	oxidation-reduction process (more)
Molecular Function	oxidoreductase activity (more)

GO Terms (all 4)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR015590 (1) InterPro:IPR016160 (1) InterPro:IPR016161 (1) InterPro:IPR016162 (1) InterPro:IPR016163 (1) InterPro:IPR029510 (1)	PROSITE:PS00070 (1) PROSITE:PS00687 (1)	Pfam:PF00171 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	aldh1a3-201 (1)	2256	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

ANTIBODIESNo data available

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM aldh1a3 No data available

MARKER RELATIONSHIPSNo data available

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_001044745 (1)	1892bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CABZ01067605 (1)	52882bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q0H2G3 (1)	513aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:83624 (1)

Sequence Information (all 19)

OTHER aldh1a3 GENE PAGES

Alliance (1)

Gene:751785 (1)

VEGA:OTTDARG00000043554 (1)

Ensembl(GRCz11):ENSDARG00000076933 (2)

ORTHOLOGY for aldh1a3 (Chr: 7)

CITATIONS (54)

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