ZFIN ID: ZDB-GENE-061110-10
Gene Name: carboxyl ester lipase, tandem duplicate 2
Gene Symbol: cel.2    Nomenclature History

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Previous Names: cell, zgc:112377, zgc:153861

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have neurexin family protein binding activity and signaling receptor activity. Predicted to be involved in several processes, including neuron cell-cell adhesion; synapse assembly; and synaptic vesicle endocytosis. Predicted to localize to the cell surface; integral component of plasma membrane; and synapse. Human ortholog(s) of this gene implicated in lipomatosis; maturity-onset diabetes of the young type 8; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human CEL (carboxyl ester lipase).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000029822 (2)
GENE EXPRESSION
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa29531 Point Mutation Unknown Premature Stop ENU
sa43592 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cel.2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    maturity-onset diabetes of the young type 8 Alliance Maturity-onset diabetes of the young, type VIII 609812
    DISEASE ASSOCIATED WITH cel.2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process lipid metabolic process (more)
    Cellular Component cell surface (more)
    Molecular Function cholinesterase activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000997 Cholinesterase
    Domain IPR002018 Carboxylesterase, type B
    Conserved_site IPR019819 Carboxylesterase type B, conserved site
    Active_site IPR019826 Carboxylesterase type B, active site
    Homologous_superfamily IPR029058 Alpha/Beta hydrolase fold
    Family IPR033560 Bile salt-activated lipase
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cel.2-201 (1)    Ensembl 1825
    Browsers: EnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cel.2 No data available
    MARKER RELATIONSHIPS
    cel.2 Contained in: [BAC] CH73-6P15 (1), DKEY-184P9 (1) (order this)
    cel.2 Encodes: [cDNA] MGC:112377 (1), MGC:153861 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA GenBank:BC076049 (1) 1837 bp
    Genomic GenBank:BX005379 (1) 185814 bp
    Select Tool
    Polypeptide UniProtKB:Q6P004 (1) 552 aa
    Sequence Information (all 10)
    ORTHOLOGY for cel.2 ( Chr: 21 )
    CITATIONS (21)