ZFIN ID: ZDB-GENE-061109-2
Gene Name: retinoblastoma-like 2 (p130)
Gene Symbol: rbl2    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have RNA polymerase II activating transcription factor binding activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and negative regulation of G1/S transition of mitotic cell cycle. Predicted to localize to chromatin and transcription regulator complex. Is expressed in neuromast. Orthologous to human RBL2 (RB transcriptional corepressor like 2).
Genome Resources: Alliance (1),  Gene:100331892 (1),  Ensembl(GRCz11):ENSDARG00000045636 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa14836 Point Mutation Unknown Splice Site ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-rbl2
1
CRISPR2-rbl2
1
CRISPR3-rbl2
1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH rbl2 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH rbl2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process regulation of cell cycle (more)
Cellular Component nucleus (more)
Molecular Function RNA polymerase II activating transcription factor binding (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA rbl2-201 (1)    Ensembl 7252
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM rbl2 No data available
MARKER RELATIONSHIPS
rbl2 Contained in: [BAC] CH73-364F24 (1)
[Fosmid] CH1073-435M20 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_002666954 (1)
Genomic GenBank:CU469312 (1) 89370 nt
Select Tool
Polypeptide UniProtKB:E7FDM3 (1) 1079 aa
Sequence Information (all 14)
ORTHOLOGY for rbl2 ( Chr: 25 )
CITATIONS (19)