Gene

cylda

ID
ZDB-GENE-061108-2
Name
cylindromatosis (turban tumor syndrome), a
Symbol
cylda Nomenclature History
Previous Names
  • cyld
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Exhibits Lys63-specific deubiquitinase activity. Involved in central nervous system morphogenesis; cranial skeletal system development; and protein linear deubiquitination. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in Brooke-Spiegler syndrome. Orthologous to human CYLD (CYLD lysine 63 deubiquitinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cylda Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Brooke-Spiegler syndrome Alliance Brooke-Spiegler syndrome 605041
Cylindromatosis, familial 132700
Trichoepithelioma, multiple familial, 1 601606
?Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 619132
Associated With cylda Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018200 Ubiquitin specific protease, conserved site
Domain IPR000938 CAP Gly-rich domain
Domain IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Domain IPR028889 Ubiquitin specific protease domain
Homologous_superfamily IPR036859 CAP Gly-rich domain superfamily
Homologous_superfamily IPR038765 Papain-like cysteine peptidase superfamily
Domain Details Per Protein
Protein Length CAP Gly-rich domain CAP Gly-rich domain superfamily Papain-like cysteine peptidase superfamily Peptidase C19, ubiquitin carboxyl-terminal hydrolase Ubiquitin specific protease, conserved site Ubiquitin specific protease domain
UniProtKB:F8W5E2 912
UniProtKB:E7FEV5 951
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations