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Gene

tnk1

ID
ZDB-GENE-030131-7427
Name
tyrosine kinase, non-receptor, 1
Symbol
tnk1 Nomenclature History
Previous Names
  • tnk2
  • ack1 (1)
  • ackb
  • tnk2b (1)
  • wu:fj16g04
  • zgc:154019
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in cell differentiation; innate immune response; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in cytoplasm. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Orthologous to human TNK1 (tyrosine kinase non receptor 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tnk1 Human Ortholog
No data available
Associated With tnk1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR001660 Sterile alpha motif domain
Domain IPR015116 Cdc42 binding domain-like
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013761 Sterile alpha motif/pointed domain superfamily
Homologous_superfamily IPR037085 Cdc42 binding domain-like superfamily
Domain Details Per Protein
Protein Length Cdc42 binding domain-like Cdc42 binding domain-like superfamily Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Sterile alpha motif domain Sterile alpha motif/pointed domain superfamily Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain
UniProtKB:E9QFR7 183
UniProtKB:A0JMM7 732
UniProtKB:F1QB24 733
UniProtKB:E9QG30 123
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Note
Based on amino acid similarity, Woods, et al. (2005. Genome Res. 15:1307-1314.) report this gene to be the ortholog of human TNK2. Subsequent analysis suggests it is the ortholog of human TNK1 and mouse Tnk1 based on amino acid similarity and conserved synteny.
Citations