Gene

capn5a

ID
ZDB-GENE-061103-214
Name
calpain 5a
Symbol
capn5a Nomenclature History
Previous Names
  • zgc:153446
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to localize to cytoplasm. Is expressed in hatching gland; nervous system; and optic vesicle. Human ortholog(s) of this gene implicated in neovascular inflammatory vitreoretinopathy. Orthologous to human CAPN5 (calpain 5).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With capn5a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
neovascular inflammatory vitreoretinopathy Alliance Vitreoretinopathy, neovascular inflammatory 193235
Associated With capn5a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR000169 Cysteine peptidase, cysteine active site
Domain IPR000008 C2 domain
Domain IPR001300 Peptidase C2, calpain, catalytic domain
Domain IPR022682 Peptidase C2, calpain, large subunit, domain III
Domain IPR022683 Peptidase C2, calpain, domain III
Domain IPR033883 Calpain subdomain III
Domain IPR033884 Calpain C2 domain
Family IPR022684 Peptidase C2, calpain family
Family IPR050420 Calpain
Homologous_superfamily IPR035892 C2 domain superfamily
Homologous_superfamily IPR036213 Calpain large subunit, domain III superfamily
Homologous_superfamily IPR038765 Papain-like cysteine peptidase superfamily
Domain Details Per Protein
Protein Length C2 domain C2 domain superfamily Calpain Calpain C2 domain Calpain large subunit, domain III superfamily Calpain subdomain III Cysteine peptidase, cysteine active site Papain-like cysteine peptidase superfamily Peptidase C2, calpain, catalytic domain Peptidase C2, calpain, domain III Peptidase C2, calpain family Peptidase C2, calpain, large subunit, domain III
UniProtKB:A0JMG3 639
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA capn5a-201 (1) Ensembl 3698 nt
mRNA capn5a-202 (1) Havana 2051 nt
mRNA capn5a-203 (1) Ensembl 1921 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations