ZFIN ID: ZDB-GENE-061103-196
Gene Name: chloride channel 7
Gene Symbol: clcn7    Nomenclature History

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Previous Names: im:7155923, zgc:153490 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have chloride transmembrane transporter activity. Predicted to be involved in chloride transport and transmembrane transport. Predicted to localize to intracellular membrane-bounded organelle. Is expressed in several structures, including EVL; blastomere; head; periderm; and pleuroperitoneal region. Used to study osteopetrosis. Human ortholog(s) of this gene implicated in autosomal dominant osteopetrosis 2 and autosomal recessive osteopetrosis 4. Orthologous to human CLCN7 (chloride voltage-gated channel 7).
Genome Resources: Alliance (1),  Gene:553351 (1),  Ensembl(GRCz11):ENSDARG00000019556 (2)
GENE EXPRESSION
All Expression Data: 9 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7155923]
  6 figures (5 images) from Thisse et al., 2004 [IMAGE:7154411]
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa2122 Point Mutation Unknown Splice Site ENU
sa14513 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa20020 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40074 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40075 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45140 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-clcn7 N/A 1
    DISEASE ASSOCIATED WITH clcn7 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant osteopetrosis 2 Alliance Osteopetrosis, autosomal dominant 2 166600
    autosomal recessive osteopetrosis 4 Alliance Osteopetrosis, autosomal recessive 4 611490
    Hypopigmentation, organomegaly, and delayed myelination and development 618541
    DISEASE ASSOCIATED WITH clcn7 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    osteopetrosis AB + MO1-clcn7 standard conditions Zhang et al., 2019
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chloride transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function voltage-gated chloride channel activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA clcn7-201 (1)    Ensembl 3971
    ncRNA clcn7-002 (1)    Ensembl 826
    clcn7-003 (1)    Ensembl 853
    clcn7-004 (1)    Ensembl 572
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM clcn7 No data available
    MARKER RELATIONSHIPS
    clcn7 Contained in: [BAC] CH211-157C3 (1)
    clcn7 Encodes: [EST] IMAGE:7154411 (1), IMAGE:7155923 (1)
    [cDNA] MGC:153490 (1), MGC:193084 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001077537 (1) 3982 nt
    Genomic GenBank:CR394572 (1) 147156 nt
    Select Tool
    Polypeptide UniProtKB:A0JMG8 (1) 795 aa
    Sequence Information (all 21)
    ORTHOLOGY for clcn7 ( Chr: 3 )
    CITATIONS (26)