ZFIN ID: ZDB-GENE-061027-130
Gene Name: kinesin family member 6
Gene Symbol: kif6    Nomenclature History

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Previous Names: skolios (1), zgc:152746 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have ATPase activity; microtubule binding activity; and microtubule motor activity. Involved in spinal cord development. Localizes to ciliary base. Is expressed in brain; intestine; ovary; and testis. Used to study idiopathic scoliosis. Orthologous to human KIF6 (kinesin family member 6).
Genome Resources: Alliance (1),  Gene:553436 (1),  Ensembl(GRCz11):ENSDARG00000053240 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Segmentation:26+ somites (22.0h-24.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
gw326 Point Mutation Unknown Premature Stop ENU
gw327 Small Deletion Exon 2 Unknown TALEN
gw328 Small Deletion Exon 2 Unknown TALEN
gw329 Small Deletion Exon 2 Unknown TALEN
sa36522 Point Mutation Unknown Splice Site, Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36523 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43002 Point Mutation Unknown Missense, Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-kif6 N/A 1
    MO2-kif6 N/A 1
    MO3-kif6 N/A 1
    TALEN1-kif6 1
    DISEASE ASSOCIATED WITH kif6 HUMAN ORTHOLOG No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process spinal cord development (more)
    Cellular Component ciliary base (more)
    Molecular Function ATP binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kif6-201 (1)    Ensembl 2918
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM kif6 No data available
    MARKER RELATIONSHIPS
    kif6 Contained in: [BAC] CH73-264H24 (1), CH73-309K8 (1)
    kif6 Encodes: [cDNA] MGC:152746 (1), MGC:192807 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001077431 (1) 2563 nt
    Genomic GenBank:CU856355 (1) 80557 nt
    Select Tool
    Polypeptide UniProtKB:E7FFQ3 (1) 761 aa
    Sequence Information (all 20)
    ORTHOLOGY for kif6 ( Chr: 17 )
    CITATIONS (23)