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ZIRC
ZFIN ID: ZDB-GENE-061019-2
Gene Name: Fas cell surface death receptor
Gene Symbol: fas    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have transmembrane signaling receptor activity. Involved in notochord development and positive regulation of apoptotic process. Predicted to localize to the integral component of membrane. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hypersensitivity disease (multiple); cystic fibrosis; leukemia (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Is expressed in several structures, including blastoderm; eye; gut; notochord; and ovary. Orthologous to human FAS (Fas cell surface death receptor).
Genome Resources: Alliance (1),  Gene:768248 (1),  Ensembl(GRCz11):ENSDARG00000043586 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Wild-type Stages, Structures: Cleavage:16-cell (1.5h-1.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa11234 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-fas N/A 1
    MO2-fas N/A 1
    DISEASE ASSOCIATED WITH fas HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autoimmune lymphoproliferative syndrome Alliance Autoimmune lymphoproliferative syndrome, type IA 601859
    {Autoimmune lymphoproliferative syndrome} 601859
    Squamous cell carcinoma, burn scar-related, somatic
    DISEASE ASSOCIATED WITH fas VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of apoptotic process (more)
    Cellular Component integral component of membrane (more)
    Molecular Function transmembrane signaling receptor activity (more)
    GO Terms (all 8)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fas-201 (1)    Ensembl 984
    ncRNA fas-002 (1)    Ensembl 732
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fas No data available
    MARKER RELATIONSHIPS
    fas Contained in: [BAC] DKEY-116M16 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_021467407 (1)
    Genomic GenBank:CU464131 (1) 43637 bp
    Select Tool
    Polypeptide UniProtKB:F1QG24 (1) 293 aa
    Sequence Clusters UniGene:150815 (1)
    Sequence Information (all 11)
    ORTHOLOGY for fas ( Chr: 17 )
    CITATIONS (33)