Gene

usp9

ID
ZDB-GENE-061019-1
Name
ubiquitin specific peptidase 9
Symbol
usp9 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. Predicted to be involved in cell migration and protein deubiquitination. Predicted to localize to cytosol and nucleus. Is expressed in endodermal cell; myotome; nervous system; pectoral fin; and solid lens vesicle. Human ortholog(s) of this gene implicated in Y-linked spermatogenic failure 2 and non-syndromic X-linked intellectual disability. Orthologous to several human genes including USP9X (ubiquitin specific peptidase 9 X-linked).
Genome Resources
Note
None
Expression
All Expression Data
Fig. 2 from Khut et al., 2007
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
Fig. 4 from K√∂glsberger et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With usp9 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
non-syndromic X-linked intellectual disability Alliance Mental retardation, X-linked 99 300919
Y-linked spermatogenic failure 2 Alliance Spermatogenic failure, Y-linked, 2 415000
Mental retardation, X-linked 99, syndromic, female-restricted 300968
Associated With usp9 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018200 Ubiquitin specific protease, conserved site
Domain IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Domain IPR028889 Ubiquitin specific protease domain
Homologous_superfamily IPR016024 Armadillo-type fold
Homologous_superfamily IPR038765 Papain-like cysteine peptidase superfamily
Domain Details Per Protein
Protein Length Armadillo-type fold Papain-like cysteine peptidase superfamily Peptidase C19, ubiquitin carboxyl-terminal hydrolase Ubiquitin specific protease, conserved site Ubiquitin specific protease domain
UniProtKB:Q4FE55 2551
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations