Gene

usp9

ID
ZDB-GENE-061019-1
Name
ubiquitin specific peptidase 9
Symbol
usp9 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. Predicted to be involved in cell migration and protein deubiquitination. Predicted to localize to cytosol and nucleus. Is expressed in endodermal cell; myotome; nervous system; pectoral fin; and solid lens vesicle. Human ortholog(s) of this gene implicated in Y-linked spermatogenic failure 2 and non-syndromic X-linked intellectual disability. Orthologous to several human genes including USP9X (ubiquitin specific peptidase 9 X-linked).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Khut et al., 2007
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Köglsberger et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With usp9 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
female-restricted syndromic X-linked intellectual disability 99 Alliance Intellectual developmental disorder, X-linked 99, syndromic, female-restricted 300968
non-syndromic X-linked intellectual disability 99 Alliance Intellectual developmental disorder, X-linked 99 300919
Y-linked spermatogenic failure 2 Alliance Spermatogenic failure, Y-linked, 2 415000
Associated With usp9 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018200 Ubiquitin specific protease, conserved site
Domain IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Domain IPR021905 Ubiquitin C-terminal hydrolase-like, DUF3517
Domain IPR028889 Ubiquitin specific protease domain
Family IPR050164 Ubiquitin carboxyl-terminal hydrolases
Homologous_superfamily IPR016024 Armadillo-type fold
Homologous_superfamily IPR038765 Papain-like cysteine peptidase superfamily
Domain Details Per Protein
Protein Length Armadillo-type fold Papain-like cysteine peptidase superfamily Peptidase C19, ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolases Ubiquitin C-terminal hydrolase-like, DUF3517 Ubiquitin specific protease, conserved site Ubiquitin specific protease domain
UniProtKB:Q4FE55 2551
UniProtKB:A0A8M3AW48 2557
UniProtKB:A0A8M3B5Q3 2593
UniProtKB:A0A8M3B2R0 2558
UniProtKB:A0A8M2BF50 2594
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA usp9-201 (1) Ensembl 7656 nt
mRNA usp9-202 (1) Havana 9655 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations