ZFIN ID: ZDB-GENE-061013-99
Gene Name: carboxylesterase 2a
Gene Symbol: ces2a    Nomenclature History

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Previous Names: ces2 (1), cbe (1), im:6908784, si:dkey-38l12.2, zgc:153863

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have carboxylic ester hydrolase activity. Predicted to localize to the extracellular space. Is expressed in liver; pectoral fin; pleuroperitoneal region; yolk; and yolk syncytial layer. Orthologous to several human genes including CES2 (carboxylesterase 2).
Genome Resources: Alliance (1),  Gene:566132 (1),  Ensembl(GRCz11):ENSDARG00000041569 (1)
Note: Some publications were mistakingly attributed to "ces2" before it was determined that there are 2 genes, ces2a and ces2b in zebrafish. The attributions have been corrected. IMPORTANT: qPCR primers for ces2 from Zhao et al. (2010) do not BLAST to any known ces2 sequences
GENE EXPRESSION
All Expression Data: 11 figures from 4 publications
Directly Submitted Expression Data: 6 figures (5 images) from Thisse et al., 2004 [IMAGE:6908784]
  3 figures (7 images) from Rauch et al., 2003 [fb58c11]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa16165 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16368 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45634 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ces2a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ces2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process biological_process (more)
    Cellular Component extracellular space (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR002018 Carboxylesterase, type B
    Conserved_site IPR019819 Carboxylesterase type B, conserved site
    Active_site IPR019826 Carboxylesterase type B, active site
    Homologous_superfamily IPR029058 Alpha/Beta hydrolase fold
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript ces2-202 (1)    Ensembl 821
    mRNA ces2-201 (1)    Ensembl 1779
    ces2-203 (1)    Ensembl 419
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ces2a No data available
    MARKER RELATIONSHIPS
    ces2a Contained in: [BAC] CH211-239N6 (1), DKEY-38L12 (1) (order this)
    ces2a Encodes: [EST] fb58c11 (1) (order this), IMAGE:6908784 (1)
    [cDNA] MGC:153863 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001077252 (1) 1781 bp
    Genomic GenBank:BX005041 (1) 190853 bp
    Select Tool
    Polypeptide UniProtKB:Q32LW0 (1) 563 aa
    Sequence Information (all 31)
    ORTHOLOGY for ces2a ( Chr: 18 )
    CITATIONS (28)