ZFIN ID: ZDB-GENE-061013-727
Gene Name: dihydropyrimidine dehydrogenase a, tandem duplicate 1
Gene Symbol: dpyda.1    Nomenclature History

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Previous Names: dpyda, zgc:153505

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have iron-sulfur cluster binding activity. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and pancreatic cancer. Orthologous to human DPYD (dihydropyrimidine dehydrogenase).
Genome Resources: Alliance (1),  Gene:768165 (1),  Ensembl(GRCz11):ENSDARG00000102671 (1)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH dpyda.1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
dihydropyrimidine dehydrogenase deficiency Alliance 5-fluorouracil toxicity 274270
Dihydropyrimidine dehydrogenase deficiency 274270
DISEASE ASSOCIATED WITH dpyda.1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process oxidation-reduction process (more)
Cellular Component cytosol (more)
Molecular Function iron-sulfur cluster binding (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA dpyda.1-201 (1)    Ensembl 1076
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM dpyda.1 No data available
MARKER RELATIONSHIPS
dpyda.1 Contained in: [BAC] CH211-235E15 (1)
dpyda.1 Encodes: [cDNA] MGC:153505 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001077308 (1) 1306 nt
Genomic GenBank:BX927311 (1) 162570 nt
Select Tool
Polypeptide UniProtKB:Q08BJ9 (1) 243 aa
Sequence Information (all 21)
ORTHOLOGY for dpyda.1 ( Chr: 24 )
CITATIONS (13)