Gene
pros1
- ID
- ZDB-GENE-061013-657
- Name
- protein S
- Symbol
- pros1 Nomenclature History
- Previous Names
-
- zgc:154001 (1)
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have calcium ion binding activity. Predicted to be involved in negative regulation of blood coagulation. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in cerebral infarction; protein S deficiency; and thrombophilia. Is expressed in hypochord. Orthologous to human PROS1 (protein S).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7158575 (3 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant thrombophilia due to protein S deficiency | Alliance | Thrombophilia 5 due to protein S deficiency, autosomal dominant | 612336 |
| autosomal recessive thrombophilia due to protein S deficiency | Alliance | Thrombophilia 5 due to protein S deficiency, autosomal recessive | 614514 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR013032 | EGF-like, conserved site |
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000294 | Gamma-carboxyglutamic acid-rich (GLA) domain |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001791 | Laminin G domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR049883 | NOTCH1 EGF-like calcium-binding domain |
| Family | IPR051145 | Growth Arrest-Specific/Sex Hormone-Binding/Vitamin K-Dependent |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR017857 | Coagulation factor-like, Gla domain superfamily |
| Homologous_superfamily | IPR035972 | Gamma-carboxyglutamic acid-rich (GLA) domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
Domain Details Per Protein
| Protein | Length | Coagulation factor-like, Gla domain superfamily | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Gamma-carboxyglutamic acid-rich (GLA) domain | Gamma-carboxyglutamic acid-rich (GLA) domain superfamily | Growth Arrest-Specific/Sex Hormone-Binding/Vitamin K-Dependent | Growth factor receptor cysteine-rich domain superfamily | Laminin G domain | NOTCH1 EGF-like calcium-binding domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q08BB9
|
673 |
Interactions and Pathways
No data available
Plasmids
No data available