Gene

pros1

ID
ZDB-GENE-061013-657
Name
protein S
Symbol
pros1 Nomenclature History
Previous Names
  • zgc:154001 (1)
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have calcium ion binding activity. Predicted to be involved in negative regulation of blood coagulation. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in cerebral infarction; protein S deficiency; and thrombophilia. Is expressed in hypochord. Orthologous to human PROS1 (protein S).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pros1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant thrombophilia due to protein S deficiency Alliance Thrombophilia 5 due to protein S deficiency, autosomal dominant 612336
autosomal recessive thrombophilia due to protein S deficiency Alliance Thrombophilia 5 due to protein S deficiency, autosomal recessive 614514
Associated With pros1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR013032 EGF-like, conserved site
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
Domain IPR000742 EGF-like domain
Domain IPR001791 Laminin G domain
Domain IPR001881 EGF-like calcium-binding domain
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily IPR017857 Coagulation factor-like, Gla domain superfamily
Homologous_superfamily IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Domain Details Per Protein
Protein Length Coagulation factor-like, Gla domain superfamily Concanavalin A-like lectin/glucanase domain superfamily EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like, conserved site EGF-like domain EGF-type aspartate/asparagine hydroxylation site Gamma-carboxyglutamic acid-rich (GLA) domain Gamma-carboxyglutamic acid-rich (GLA) domain superfamily Growth factor receptor cysteine-rich domain superfamily Laminin G domain
UniProtKB:Q08BB9 673
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations