ZFIN ID: ZDB-GENE-061013-59
Gene Name: forkhead box O1 a
Gene Symbol: foxo1a    Nomenclature History

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Previous Names: foxo1, foxo1a.1 (1), zgc:153388

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific; sequence-specific DNA binding activity; and transcription factor binding activity. Involved in several processes, including gluconeogenesis; lymph vessel development; and smooth muscle cell proliferation. Predicted to localize to cytoplasm and nucleus. Is expressed in digestive system; head mesenchyme; pericardial region; and pharyngeal arch. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to human FOXO1 (forkhead box O1).
Genome Resources: Alliance (1),  Gene:768121 (1),  Ensembl(GRCz11):ENSDARG00000099555 (1)
GENE EXPRESSION
All Expression Data: 7 figures from 7 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb390 Small Deletion Exon 1 Unknown CRISPR
ihb391 Small Deletion Exon 1 Unknown CRISPR
sa849 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-foxo1a
    2
    CRISPR2-foxo1a 1
    MO1-foxo1a N/A 1
    MO2-foxo1a N/A 1
    MO3-foxo1a N/A 1
    MO4-foxo1a N/A 1
    MO5-foxo1a N/A 1
    DISEASE ASSOCIATED WITH foxo1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    alveolar rhabdomyosarcoma Alliance Rhabdomyosarcoma, alveolar 268220
    DISEASE ASSOCIATED WITH foxo1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process gluconeogenesis (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA foxo1a-201 (1)    Ensembl 5915
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM foxo1a No data available
    MARKER RELATIONSHIPS
    foxo1a Contained in: [BAC] CH211-203F4 (1)
    foxo1a Encodes: [cDNA] MGC:153388 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001077257 (1) 1959 nt
    Genomic GenBank:BX649258 (1) 148199 nt
    Select Tool
    Polypeptide UniProtKB:A3RK74 (1) 652 aa
    Sequence Information (all 18)
    ORTHOLOGY for foxo1a ( Chr: 15 )
    CITATIONS (41)