Gene

proza

ID
ZDB-GENE-061013-403
Name
protein Z, vitamin K-dependent plasma glycoprotein a
Symbol
proza Nomenclature History
Previous Names
  • wu:fj51g06
  • zgc:152997 (1)
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to enable calcium ion binding activity and serine-type endopeptidase activity. Predicted to act upstream of or within blood coagulation and proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Behcet's disease and brain ischemia. Orthologous to human PROZ (protein Z, vitamin K dependent plasma glycoprotein).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With proza Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
[Protein Z deficiency] 614024
Associated With proza Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
Domain IPR000742 EGF-like domain
Domain IPR001254 Serine proteases, trypsin domain
Domain IPR001881 EGF-like calcium-binding domain
Family IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
Homologous_superfamily IPR009003 Peptidase S1, PA clan
Homologous_superfamily IPR017857 Coagulation factor-like, Gla domain superfamily
Homologous_superfamily IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
Homologous_superfamily IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Domain Details Per Protein
Protein Length Coagulation factor-like, Gla domain superfamily EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like domain EGF-type aspartate/asparagine hydroxylation site Gamma-carboxyglutamic acid-rich (GLA) domain Gamma-carboxyglutamic acid-rich (GLA) domain superfamily Peptidase S1A, coagulation factor VII/IX/X/C/Z Peptidase S1, PA clan Peptidase S1, PA clan, chymotrypsin-like fold Serine proteases, trypsin domain
UniProtKB:A0A286Y878 198
UniProtKB:Q08BQ2 196
UniProtKB:F1Q5S2 426
UniProtKB:F1Q6I8 196
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations