Gene

clcn4

ID
ZDB-GENE-061013-353
Name
chloride channel, voltage-sensitive 4
Symbol
clcn4 Nomenclature History
Previous Names
  • zgc:153764
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have solute:proton antiporter activity and voltage-gated chloride channel activity. Predicted to be involved in chloride transport and transmembrane transport. Predicted to localize to Golgi apparatus; cytoplasmic vesicle; and integral component of plasma membrane. Is expressed in brain; eye; gill; heart; and immune system. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability. Orthologous to human CLCN4 (chloride voltage-gated channel 4).
Genome Resources
Note
None
Expression
All Expression Data
1 figure from Wang et al., 2015
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With clcn4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Raynaud-Claes syndrome Alliance Raynaud-Claes syndrome 300114
Associated With clcn4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000644 CBS domain
Family IPR001807 Chloride channel, voltage gated
Family IPR002246 Chloride channel ClC-4
Homologous_superfamily IPR014743 Chloride channel, core
Domain Details Per Protein
Protein Length CBS domain Chloride channel ClC-4 Chloride channel, core Chloride channel, voltage gated
UniProtKB:Q08BG8 768
UniProtKB:F1QXH5 768
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations