ZFIN ID: ZDB-GENE-061013-353
Gene Name: chloride channel, voltage-sensitive 4
Gene Symbol: clcn4    Nomenclature History

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Previous Name: zgc:153764

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have chloride ion binding activity; solute:proton antiporter activity; and voltage-gated chloride channel activity. Predicted to be involved in chloride transport and transmembrane transport. Predicted to localize to Golgi apparatus; cytoplasmic vesicle; and integral component of plasma membrane. Is expressed in brain; eye; gill; heart; and immune system. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability. Orthologous to human CLCN4 (chloride voltage-gated channel 4).
Genome Resources: Alliance (1),  Gene:768175 (1),  Ensembl(GRCz11):ENSDARG00000035808 (2)
GENE EXPRESSION
All Expression Data: Fig. 2 from Wang et al., 2015
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa41919 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41920 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-clcn4
    1
    CRISPR2-clcn4
    1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH clcn4 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    non-syndromic X-linked intellectual disability Alliance Raynaud-Claes syndrome 300114
    DISEASE ASSOCIATED WITH clcn4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chloride transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function voltage-gated chloride channel activity (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM clcn4 No data available
    MARKER RELATIONSHIPS
    clcn4 Encodes: [cDNA] MGC:153764 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001077318 (1) 2825 nt
    Polypeptide UniProtKB:F1QXH5 (1) 768 aa
    Sequence Information (all 9)
    ORTHOLOGY for clcn4 ( Chr: 11 )
    CITATIONS (18)