Gene

il1rapl1a

ID
ZDB-GENE-061013-249
Name
interleukin 1 receptor accessory protein-like 1a
Symbol
il1rapl1a Nomenclature History
Previous Names
  • fi18g04
  • wu:fi18g04
  • zgc:152866 (1)
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to enable NAD(P)+ nucleosidase activity; NAD+ nucleotidase, cyclic ADP-ribose generating; and interleukin-1 receptor activity. Predicted to be involved in negative regulation of exocytosis. Predicted to act upstream of or within signal transduction. Predicted to be located in cytoplasm and plasma membrane. Is expressed in optic tectum and telencephalon. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability 21. Orthologous to human IL1RAPL1 (interleukin 1 receptor accessory protein like 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Yoshida et al., 2008
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With il1rapl1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
non-syndromic X-linked intellectual disability 21 Alliance Intellectual developmental disorder, X-linked 21 300143
Associated With il1rapl1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR041416 IL-1Ra-like, immunoglobulin domain
Family IPR004074 Interleukin-1 receptor type I/II
Family IPR015621 Interleukin-1 receptor family
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length IL-1Ra-like, immunoglobulin domain Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 Interleukin-1 receptor family Interleukin-1 receptor type I/II Toll/interleukin-1 receptor homology (TIR) domain Toll/interleukin-1 receptor homology (TIR) domain superfamily
UniProtKB:B6ZK76 701
UniProtKB:E9QD35 744
UniProtKB:A0A2R8QPU9 695
UniProtKB:E9QFM7 549
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations