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ZIRC
ZFIN ID: ZDB-GENE-061013-24
Gene Name: mitochondrial calcium uniporter
Gene Symbol: mcu    Nomenclature History

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Previous Names: ccdc109a, wu:fi24a01, zgc:153607 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Exhibits identical protein binding activity. Involved in several processes, including actin filament organization; calcium import into the mitochondrion; and convergent extension involved in gastrulation. Predicted to localize to the integral component of mitochondrial inner membrane and uniplex complex. Is expressed in brain; heart; heart tube; and visceral fat. Orthologous to human MCU (mitochondrial calcium uniporter).
Genome Resources: Alliance (1),  Gene:768182 (1),  Ensembl(GRCz11):ENSDARG00000101175 (1)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ct149aGt Transgenic Insertion Unknown Unknown DNA
la027461Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22206 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tpl124 Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-mcu
    1
    CRISPR2-mcu 1
    CRISPR3-mcu
    1
    MO1-mcu N/A 1
    MO2-mcu N/A 1
    MO3-mcu N/A 1
    TALEN1-mcu
    1
    DISEASE ASSOCIATED WITH mcu HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH mcu VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process calcium import into the mitochondrion (more)
    Cellular Component integral component of mitochondrial inner membrane (more)
    Molecular Function identical protein binding (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR006769 (1)
  • InterPro:IPR039055 (1)
  • Pfam:PF04678 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mcu-201 (1)    Ensembl 1323
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mcu No data available
    MARKER RELATIONSHIPS
    mcu Contained in: [BAC] CH73-57A19 (1) (order this)
    [Fosmid] CH1073-92F7 (1) (order this), CH1073-423J5 (1) (order this), ZFOS-289A11 (1)
    mcu Encodes: [EST] fi24a01
    [cDNA] MGC:153607 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001077325 (1) 1898 bp
    Genomic GenBank:CU856520 (1) 108204 bp
    Select Tool
    Polypeptide UniProtKB:F1QT29 (1) 376 aa
    Sequence Clusters UniGene:122221 (1)
    Sequence Information (all 25)
    ORTHOLOGY for mcu ( Chr: 13 )
    CITATIONS (32)