Gene

zgc:152891

ID

ZDB-GENE-061013-229

Name

zgc:152891

Symbol

zgc:152891 Nomenclature History

Previous Names

alox12b (1)
ALOX4b (1)
wu:fi89d03
zgc:153926

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have iron ion binding activity and linoleate 13S-lipoxygenase activity. Predicted to be involved in oxidation-reduction process. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1; autosomal recessive congenital ichthyosis 2; and autosomal recessive congenital ichthyosis 3. Orthologous to human ALOX12B (arachidonate 12-lipoxygenase, 12R type); ALOX15B (arachidonate 15-lipoxygenase type B); and ALOXE3 (arachidonate lipoxygenase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With zgc:152891 Human Ortholog

No data available

Associated With zgc:152891 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020834	Lipoxygenase, conserved site
Domain	IPR001024	PLAT/LH2 domain
Domain	IPR013819	Lipoxygenase, C-terminal
Family	IPR000907	Lipoxygenase
Family	IPR001885	Lipoxygenase, mammalian
Homologous_superfamily	IPR036226	Lipoxigenase, C-terminal domain superfamily
Homologous_superfamily	IPR036392	PLAT/LH2 domain superfamily