ZFIN ID: ZDB-GENE-061013-229
Gene Name: zgc:152891
Gene Symbol: zgc:152891    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: alox12b (1), ALOX4b (1), wu:fi89d03, zgc:153926

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have iron ion binding activity and linoleate 13S-lipoxygenase activity. Predicted to be involved in oxidation-reduction process. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1; autosomal recessive congenital ichthyosis 2; and autosomal recessive congenital ichthyosis 3. Orthologous to human ALOX12B (arachidonate 12-lipoxygenase, 12R type); ALOX15B (arachidonate 15-lipoxygenase type B); and ALOXE3 (arachidonate lipoxygenase 3).
Genome Resources: Alliance (1),  Gene:767741 (1),  Ensembl(GRCz11):ENSDARG00000016789 (2)

Nomenclature Note: This gene is characterized by full length cDNAs isolated as part of the Zebrafish Gene Collection (ZGC). When more is known about the gene, the current nomenclature will be replaced with more traditional zebrafish gene nomenclature. The prefix `zgc:' indicates that this gene is represented by cDNAs generated by the ZGC project.

MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028351Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16077 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37349 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH zgc:152891 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH zgc:152891 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process oxidation-reduction process (more)
    Cellular Component cellular_component (more)
    Molecular Function dioxygenase activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000907 Lipoxygenase
    Domain IPR001024 PLAT/LH2 domain
    Family IPR001885 Lipoxygenase, mammalian
    Domain IPR013819 Lipoxygenase, C-terminal
    Conserved_site IPR020834 Lipoxygenase, conserved site
    Homologous_superfamily IPR036226 Lipoxigenase, C-terminal domain superfamily
    Homologous_superfamily IPR036392 PLAT/LH2 domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA zgc:152891-201 (1)    Ensembl 2204
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM zgc:152891 No data available
    MARKER RELATIONSHIPS
    zgc:152891 Contained in: [BAC] CH211-241E20 (1)
    zgc:152891 Encodes: [EST] fi89d03
    [cDNA] MGC:152891 (1), MGC:153926 (1), MGC:192554 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001076710 (1)
    Genomic GenBank:CT574573 (1) 142754 bp
    Select Tool
    Polypeptide UniProtKB:F1QKM3 (1) 663 aa
    Sequence Information (all 25)
    ORTHOLOGY for zgc:152891 ( Chr: 21 )
    CITATIONS (21)