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Gene

setdb1b

ID
ZDB-GENE-061013-224
Name
SET domain bifurcated histone lysine methyltransferase 1b
Symbol
setdb1b Nomenclature History
Previous Names
  • im:7143091
  • wu:fa04a12
  • wu:fj80h02
  • zgc:152899
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to enable histone methyltransferase activity (H3-K9 specific) and promoter-specific chromatin binding activity. Predicted to be involved in several processes, including Ras protein signal transduction; chromatin organization; and positive regulation of DNA methylation-dependent heterochromatin assembly. Predicted to act upstream of or within histone lysine methylation. Predicted to be located in chromosome. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autistic disorder and lung cancer. Orthologous to human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With setdb1b Human Ortholog
No data available
Associated With setdb1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001214 SET domain
Domain IPR001739 Methyl-CpG DNA binding
Domain IPR002999 Tudor domain
Domain IPR003616 Post-SET domain
Domain IPR007728 Pre-SET domain
Domain IPR040880 Domain of unknown function DUF5604
Domain IPR041291 Histone methyltransferase, Tudor domain 1
Domain IPR041292 Histone methyltransferase, Tudor domain 2
Family IPR025796 Histone-lysine N-methyltransferase SETDB1
Homologous_superfamily IPR016177 DNA-binding domain superfamily
Domain Details Per Protein
Protein Length DNA-binding domain superfamily Domain of unknown function DUF5604 Histone-lysine N-methyltransferase SETDB1 Histone methyltransferase, Tudor domain 1 Histone methyltransferase, Tudor domain 2 Methyl-CpG DNA binding Post-SET domain Pre-SET domain SET domain Tudor domain
UniProtKB:A0A0R4IPA3 1214
UniProtKB:A0A0R4IUW4 1242
UniProtKB:A0A0R4IT84 100
UniProtKB:B2GRL9 886
UniProtKB:Q08BR4 1216
UniProtKB:A0A0R4IUJ3 279
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations