ZFIN ID: ZDB-GENE-061009-26
Gene Name: leucine rich repeat containing 8 VRAC subunit Da
Gene Symbol: lrrc8da    Nomenclature History

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Previous Names: im:7140212, si:ch211-83f14.3

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine phosphatase activity and volume-sensitive anion channel activity. Predicted to be involved in aspartate transmembrane transport; cellular response to osmotic stress; and taurine transport. Predicted to localize to cytoplasm; integral component of plasma membrane; and ion channel complex. Is expressed in several structures, including axis; pancreatic bud; polster; ventral mesenchyme; and yolk syncytial layer. Orthologous to human LRRC8D (leucine rich repeat containing 8 VRAC subunit D).
Genome Resources: Alliance (1),  Gene:497399 (1),  Ensembl(GRCz11):ENSDARG00000103370 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa19743 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH lrrc8da HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH lrrc8da VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component integral component of membrane (more)
    GO Terms (all 2)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lrrc8da-202 (1)    Ensembl 5389
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lrrc8da No data available
    MARKER RELATIONSHIPS
    lrrc8da Contained in: [BAC] CH211-83F14 (1)
    lrrc8da Encodes: [EST] IMAGE:7140212 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_002660814 (1) 3485 nt
    Genomic GenBank:BX927353 (1) 94558 nt
    Select Tool
    Polypeptide UniProtKB:A2BIH6 (1) 825 aa
    Sequence Information (all 7)
    ORTHOLOGY for lrrc8da ( Chr: 2 )
    CITATIONS (17)