ZFIN ID: ZDB-GENE-060929-990
Gene Name: solute carrier family 18 member 3a
Gene Symbol: slc18a3a    Nomenclature History

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Previous Names: vachta (1), vesicular acetylcholine transporter a (1), zgc:153442

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have acetylcholine transmembrane transporter activity. Predicted to be involved in chemical synaptic transmission. Predicted to localize to AP-1 adaptor complex; AP-2 adaptor complex; and terminal bouton. Is expressed in brain; retina; and spinal cord. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 21. Orthologous to human SLC18A3 (solute carrier family 18 member A3).
Genome Resources: Alliance (1),  Gene:559347 (1),  Ensembl(GRCz11):ENSDARG00000006356 (2)
GENE EXPRESSION
All Expression Data: 2 figures from Hong et al., 2013
Wild-type Stages, Structures: Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa16779 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42217 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-slc18a3a 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH slc18a3a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital myasthenic syndrome 21 Alliance Myasthenic syndrome, congenital, 21, presynaptic 617239
    DISEASE ASSOCIATED WITH slc18a3a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process neurotransmitter transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function transmembrane transporter activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA slc18a3a-201 (1)    Ensembl 2406
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM slc18a3a No data available
    MARKER RELATIONSHIPS
    slc18a3a Contained in: [BAC] CH211-232K3 (1)
    slc18a3a Encodes: [cDNA] MGC:153442 (1), MGC:192476 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001077550 (1) 2423 nt
    Genomic GenBank:BX855592 (1) 159646 nt
    Select Tool
    Polypeptide UniProtKB:B2GS60 (1) 513 aa
    Sequence Information (all 13)
    ORTHOLOGY for slc18a3a ( Chr: 13 )
    CITATIONS (23)