ZFIN ID: ZDB-GENE-060929-860
Gene Name: centromere protein E
Gene Symbol: cenpe    Nomenclature History

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Previous Names: wu:fc06a10, zgc:152925 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have ATPase activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement and mitotic metaphase plate congression. Predicted to localize to kinesin complex and microtubule. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 13. Orthologous to human CENPE (centromere protein E).
Genome Resources: Alliance (1),  Gene:767754 (1),  Ensembl(GRCz11):ENSDARG00000063385 (2)
GENE EXPRESSION
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa19390 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24832 Point Mutation Unknown Premature Stop ENU
    sa32570 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32571 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko13a Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cenpe 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cenpe HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    primary autosomal recessive microcephaly 13 Alliance ?Microcephaly 13, primary, autosomal recessive 616051
    DISEASE ASSOCIATED WITH cenpe VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process microtubule-based movement (more)
    Molecular Function ATP binding (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cenpe-202 (1)    Ensembl 8469
    cenpe-203 (1)    Ensembl 514
    cenpe-205 (1)    Ensembl 509
    cenpe-206 (1)    Ensembl 942
    ncRNA cenpe-003 (1)    Ensembl 534
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cenpe No data available
    MARKER RELATIONSHIPS
    cenpe Contained in: [BAC] CH211-129C2 (1)
    cenpe Encodes: [EST] fc06a10
    [cDNA] MGC:152925 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001076721 (1) 1522 nt
    Genomic GenBank:CU179747 (1) 162432 nt
    Select Tool
    Polypeptide UniProtKB:E7F2U4 (1) 2690 aa
    Sequence Information (all 22)
    ORTHOLOGY for cenpe ( Chr: 1 )
    CITATIONS (20)