ZFIN ID: ZDB-GENE-060929-836
Gene Name: angiogenic factor with G patch and FHA domains 1
Gene Symbol: aggf1    Nomenclature History

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Previous Names: im:7146636, zgc:152959

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have nucleic acid binding activity. Involved in blood vessel development; hemangioblast cell differentiation; and positive regulation of protein kinase B signaling. Is expressed in several structures, including blastomere; brain; cardiovascular system; head; and liver. Orthologous to human AGGF1 (angiogenic factor with G-patch and FHA domains 1).
Genome Resources: Alliance (1),  Gene:559905 (1),  Ensembl(GRCz11):ENSDARG00000060109 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa23854 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43584 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-aggf1 N/A 4
    MO2-aggf1 N/A 3
    DISEASE ASSOCIATED WITH aggf1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH aggf1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angiogenesis (more)
    Molecular Function nucleic acid binding (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000253 Forkhead-associated (FHA) domain
    Domain IPR000467 G-patch domain
    Homologous_superfamily IPR008984 SMAD/FHA domain superfamily
    Domain IPR035624 AGGF1, OCRE domain
    Domain IPR041591 OCRE domain
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM aggf1 No data available
    MARKER RELATIONSHIPS
    aggf1 Encodes: [EST] IMAGE:7146636 (1)
    [cDNA] MGC:152959 (1), MGC:192793 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001079982 (1)
    Genomic GenBank:CABZ01066457 (1) 8638 bp
    Polypeptide UniProtKB:F1RD88 (1) 775 aa
    Sequence Information (all 24)
    ORTHOLOGY for aggf1 ( Chr: 21 )
    CITATIONS (22)