ZFIN ID: ZDB-GENE-060929-80
Gene Name: MAP/microtubule affinity-regulating kinase 3b
Gene Symbol: mark3b    Nomenclature History

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Previous Names: si:dkeyp-50f7.6, zgc:153725

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine kinase activity and tau-protein kinase activity. Predicted to be involved in intracellular signal transduction and microtubule cytoskeleton organization. Predicted to localize to cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in visual impairment and progressive phthisis bulbi. Orthologous to human MARK3 (microtubule affinity regulating kinase 3).
Genome Resources: Alliance (1),  Gene:767634 (1),  Ensembl(GRCz11):ENSDARG00000026630 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028278Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43522 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mark3b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    visual impairment and progressive phthisis bulbi Alliance ?Visual impairment and progressive phthisis bulbi 618283
    DISEASE ASSOCIATED WITH mark3b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process phosphorylation (more)
    Cellular Component cytoplasm (more)
    Molecular Function ATP binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mark3b-201 (1)    Ensembl 4411
    mark3b-203 (1)    Ensembl 640
    ncRNA mark3b-002 (1)    Ensembl 1263
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mark3b No data available
    MARKER RELATIONSHIPS
    mark3b Contained in: [BAC] CH73-167M14 (1), CH211-154A19 (1), DKEYP-50F7 (1)
    [Fosmid] CH1073-411H1 (1)
    mark3b Encodes: [cDNA] MGC:153725 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001076575 (1) 1269 nt
    Genomic GenBank:CU915764 (1) 145064 nt
    Select Tool
    Polypeptide UniProtKB:A2CEF7 (1) 754 aa
    Sequence Information (all 34)
    ORTHOLOGY for mark3b ( Chr: 20 )
    CITATIONS (21)