ZFIN ID: ZDB-GENE-060929-712
Gene Name: iron-sulfur cluster assembly factor IBA57
Gene Symbol: iba57    Nomenclature History

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Previous Name: zgc:153540

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Involved in heme biosynthetic process. Is expressed in intermediate cell mass of mesoderm. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 74 and multiple mitochondrial dysfunctions syndrome 3. Orthologous to human IBA57 (iron-sulfur cluster assembly factor IBA57).
Genome Resources: Alliance (1),  Gene:100330979 (1),  Ensembl(GRCz11):ENSDARG00000063446 (2)
GENE EXPRESSION
All Expression Data: Fig. 3 from Nilsson et al., 2009
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-iba57 N/A 1
DISEASE ASSOCIATED WITH iba57 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary spastic paraplegia 74 Alliance ?Spastic paraplegia 74, autosomal recessive 616451
multiple mitochondrial dysfunctions syndrome 3 Alliance Multiple mitochondrial dysfunctions syndrome 3 615330
DISEASE ASSOCIATED WITH iba57 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process heme biosynthetic process (more)
Cellular Component mitochondrial matrix (more)
GO Terms (all 3)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA iba57-201 (1)    Ensembl 1350
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM iba57 No data available
MARKER RELATIONSHIPS
iba57 Contained in: [Fosmid] CH1073-162B20 (1)
iba57 Encodes: [cDNA] MGC:153540 (1), MGC:174212 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001076635 (1) 1358 nt
Genomic GenBank:CU633991 (1) 38299 nt
Select Tool
Polypeptide UniProtKB:A8E5A6 (1) 276 aa
Sequence Information (all 14)
ORTHOLOGY for iba57 ( Chr: 2 )
CITATIONS (16)