ZFIN ID: ZDB-GENE-060929-704
Gene Name: muscleblind-like splicing regulator 1
Gene Symbol: mbnl1    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: zgc:153954

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have RNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to localize to the cytoplasm and nucleoplasm. Is expressed in several structures, including blood; eye; gonad; heart; and swim bladder. Orthologous to human MBNL1 (muscleblind like splicing regulator 1).
Genome Resources: Alliance (1),  Gene:767696 (1),  Ensembl(GRCz11):ENSDARG00000052978 (2)
GENE EXPRESSION
All Expression Data: 5 figures from 4 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la014992Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33021 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45120 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mbnl1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH mbnl1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of alternative mRNA splicing, via spliceosome (more)
    Cellular Component cytoplasm (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000571 Zinc finger, CCCH-type
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mbnl1-003 (1) 821
    mbnl1-005 (1) 494
    mbnl1-205 (1)    Ensembl 687
    mbnl1-206 (1)    Ensembl 651
    ncRNA mbnl1-004 (1) 187
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mbnl1 No data available
    MARKER RELATIONSHIPS
    mbnl1 Contained in: [BAC] CH73-243C6 (1)
    mbnl1 Encodes: [cDNA] MGC:153954 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001100050 (1) 1916 bp
    Genomic GenBank:CU929191 (1) 63615 bp
    Select Tool
    Polypeptide UniProtKB:A9UH06 (1) 424 aa
    Sequence Information (all 26)
    ORTHOLOGY for mbnl1 ( Chr: 2 )
    CITATIONS (23)