ZFIN ID: ZDB-GENE-060929-60
Gene Name: methyltransferase like 13
Gene Symbol: mettl13    Nomenclature History

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Previous Names: si:dkey-19f21.2, zgc:152769

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have methyltransferase activity. Predicted to be involved in protein methylation. Is expressed in brain and inner ear. Orthologous to human EEF1AKNMT (eEF1A lysine and N-terminal methyltransferase).
Genome Resources: Alliance (1),  Gene:557908 (1),  Ensembl(GRCz11):ENSDARG00000010905 (2)
GENE EXPRESSION
All Expression Data: Fig. 2 from Yousaf et al., 2018
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9568 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10291 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15174 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa29323 Point Mutation Unknown Missense ENU
    sa43401 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mettl13 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?{Deafness, autosomal recessive 26, modifier of} 605429
    DISEASE ASSOCIATED WITH mettl13 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process metabolic process (more)
    Cellular Component cellular_component (more)
    Molecular Function catalytic activity (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Homologous_superfamily IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
    Domain IPR041698 Methyltransferase domain 25
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mettl13-201 (1)    Ensembl 3562
    mettl13-202 (1)    Ensembl 1440
    mettl13-203 (1)    Ensembl 739
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mettl13 No data available
    MARKER RELATIONSHIPS
    mettl13 Contained in: [BAC] CH73-18J6 (1), DKEY-19F21 (order this)
    mettl13 Encodes: [cDNA] MGC:152769 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001044769 (1) 2625 bp
    Genomic GenBank:BX470128 (1) 209360 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A5WVX1 (1) 690 aa
    Sequence Information (all 16)
    ORTHOLOGY for mettl13 ( Chr: 20 )
    CITATIONS (20)