ZFIN ID: ZDB-GENE-060929-256
Gene Name: lectin, mannose-binding 2-like b
Gene Symbol: lman2lb    Nomenclature History

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Previous Names: im:6907430, si:dkey-49o11.6, zgc:153375 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have mannose binding activity. Predicted to be involved in Golgi organization; endoplasmic reticulum organization; and endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to localize to several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi membrane; and endoplasmic reticulum-Golgi intermediate compartment. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human LMAN2L (lectin, mannose binding 2 like).
Genome Resources: Alliance (1),  Gene:767766 (1),  Ensembl(GRCz11):ENSDARG00000088663 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:6907430]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa38474 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH lman2lb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?Mental retardation, autosomal recessive, 52 616887
    DISEASE ASSOCIATED WITH lman2lb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process endoplasmic reticulum organization (more)
    Cellular Component integral component of membrane (more)
    Molecular Function mannose binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lman2lb No data available
    MARKER RELATIONSHIPS
    lman2lb Contained in: [BAC] DKEY-49O11 (1) (order this)
    lman2lb Encodes: [EST] IMAGE:6907430 (1)
    [cDNA] MGC:153375 (1), MGC:192415 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001076733 (1)
    Genomic GenBank:BX927282 (1) 204699 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B2GS04 (1) 354 aa
    Sequence Information (all 16)
    ORTHOLOGY for lman2lb ( Chr: 5 )
    CITATIONS (20)