ZFIN ID: ZDB-GENE-060929-120
Gene Name: mitochondrial methionyl-tRNA formyltransferase
Gene Symbol: mtfmt    Nomenclature History

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Previous Name: zgc:152651

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have methionyl-tRNA formyltransferase activity. Predicted to be involved in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 15 and mitochondrial complex I deficiency. Orthologous to human MTFMT (mitochondrial methionyl-tRNA formyltransferase).
Genome Resources: Alliance (1),  Gene:556680 (1),  Ensembl(GRCz11):ENSDARG00000005448 (2)
GENE EXPRESSION
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa41024 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    TALEN1-mtfmt
    1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mtfmt HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    combined oxidative phosphorylation deficiency 15 Alliance Combined oxidative phosphorylation deficiency 15 614947
    Mitochondrial complex I deficiency, nuclear type 27 618248
    DISEASE ASSOCIATED WITH mtfmt VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process biosynthetic process (more)
    Cellular Component mitochondrion (more)
    Molecular Function hydroxymethyl-, formyl- and related transferase activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mtfmt-201 (1)    Ensembl 1655
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mtfmt No data available
    MARKER RELATIONSHIPS
    mtfmt Contained in: [BAC] CH211-258F15 (1)
    mtfmt Encodes: [cDNA] MGC:152651 (1), MGC:165397 (1), MGC:174214 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001077542 (1) 1664 nt
    Genomic GenBank:BX470169 (1) 222405 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A5PL71 (1) 390 aa
    Sequence Information (all 15)
    ORTHOLOGY for mtfmt ( Chr: 7 )
    CITATIONS (18)