Gene

srgap2

ID
ZDB-GENE-060915-2
Name
SLIT-ROBO Rho GTPase activating protein 2
Symbol
srgap2 Nomenclature History
Previous Names
  • srgap2
  • srgap2a
  • wu:fb47h12
  • zgc:136814
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have GTPase activator activity; Rac GTPase binding activity; and protein homodimerization activity. Predicted to be involved in actin filament severing; filopodium assembly; and generation of neurons. Predicted to localize to several cellular components, including dendritic spine head; phagocytic vesicle; and postsynaptic density. Orthologous to human SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Pan et al., 2017
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Pan et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With srgap2 Human Ortholog
No data available
Associated With srgap2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000198 Rho GTPase-activating protein domain
Domain IPR001060 FCH domain
Domain IPR001452 SH3 domain
Domain IPR031160 F-BAR domain
Domain IPR035648 srGAP1/2/3, SH3 domain
Homologous_superfamily IPR008936 Rho GTPase activation protein
Homologous_superfamily IPR027267 AH/BAR domain superfamily
Homologous_superfamily IPR036028 SH3-like domain superfamily
Domain Details Per Protein
Protein Length AH/BAR domain superfamily F-BAR domain FCH domain Rho GTPase-activating protein domain Rho GTPase activation protein SH3 domain SH3-like domain superfamily srGAP1/2/3, SH3 domain
UniProtKB:B0S6J3 1100
UniProtKB:A0A8M2BK74 1091
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations