Gene

scn1lab

ID
ZDB-GENE-060906-1
Name
sodium channel, voltage-gated, type I like, alpha b
Symbol
scn1lab Nomenclature History
Previous Names
  • zscn2 (1)
  • did
  • didy
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have voltage-gated sodium channel activity. Involved in several processes, including neuronal action potential; regulation of generation of precursor metabolites and energy; and swimming behavior. Predicted to localize to axon and voltage-gated sodium channel complex. Is expressed in heart and nervous system. Used to study Dravet syndrome; anxiety disorder; and epilepsy. Human ortholog(s) of this gene implicated in epilepsy (multiple) and familial hemiplegic migraine 3. Orthologous to human SCN1A (sodium voltage-gated channel alpha subunit 1) and SCN2A (sodium voltage-gated channel alpha subunit 2).
Genome Resources
Note
None
Expression
All Expression Data
8 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
29 figures from 11 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With scn1lab Human Ortholog
No data available
Associated With scn1lab Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Domain IPR005821 Ion transport domain
Domain IPR010526 Sodium ion transport-associated
Domain IPR024583 Voltage-gated Na+ ion channel, cytoplasmic domain
Family IPR001696 Voltage gated sodium channel, alpha subunit
Homologous_superfamily IPR027359 Voltage-dependent channel domain superfamily
Domain Details Per Protein
Protein Length Ion transport domain IQ motif, EF-hand binding site Sodium ion transport-associated Voltage-dependent channel domain superfamily Voltage-gated Na+ ion channel, cytoplasmic domain Voltage gated sodium channel, alpha subunit
UniProtKB:Q20JQ8 1996
UniProtKB:F1QXF5 1996
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations