Gene

gck

ID
ZDB-GENE-060825-204
Name
glucokinase (hexokinase 4)
Symbol
gck Nomenclature History
Previous Names
  • DrGLK (1)
  • fb57f10
  • hex4 (1)
  • wu:fb57f10 (1)
  • zgc:153643
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have fructokinase activity; glucokinase activity; and mannokinase activity. Involved in glucose homeostasis; pancreas regeneration; and type B pancreatic cell development. Predicted to localize to cytosol and mitochondrion. Is expressed in brain; digestive system; female organism; heart; and muscle. Human ortholog(s) of this gene implicated in artery disease (multiple); familial hyperinsulinemic hypoglycemia 3; and glucose metabolism disease (multiple). Orthologous to human GCK (glucokinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
27 figures from 22 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from O'Hare et al., 2016
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gck Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Diabetes mellitus, noninsulin-dependent, late onset 125853
Diabetes mellitus, permanent neonatal 1 606176
Hyperinsulinemic hypoglycemia, familial, 3 602485
MODY, type II 125851
Associated With gck Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR019807 Hexokinase, binding site
Domain IPR022672 Hexokinase, N-terminal
Domain IPR022673 Hexokinase, C-terminal
Family IPR001312 Hexokinase
Homologous_superfamily IPR043129 ATPase, nucleotide binding domain
Domain Details Per Protein
Protein Length ATPase, nucleotide binding domain Hexokinase Hexokinase, binding site Hexokinase, C-terminal Hexokinase, N-terminal
UniProtKB:F1RC38 476
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA gck-201 (1) Havana 1427 nt
mRNA gck-202 (1) Ensembl 2495 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations