ZFIN ID: ZDB-GENE-060825-204
Gene Name: glucokinase (hexokinase 4)
Gene Symbol: gck    Nomenclature History

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Previous Names: DrGLK (1), fb57f10, hex4 (1), wu:fb57f10 (1), zgc:153643

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have fructokinase activity; glucokinase activity; and mannokinase activity. Involved in glucose homeostasis; pancreas regeneration; and type B pancreatic cell development. Predicted to localize to cytosol and mitochondrion. Is expressed in brain; digestive system; female organism; heart; and muscle. Human ortholog(s) of this gene implicated in artery disease (multiple); familial hyperinsulinemic hypoglycemia 3; and glucose metabolism disease (multiple). Orthologous to human GCK (glucokinase).
Genome Resources: Alliance (1),  Gene:751668 (1),  Ensembl(GRCz11):ENSDARG00000068006 (2)
GENE EXPRESSION
All Expression Data: 18 figures from 14 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa7152 Point Mutation Unknown Premature Stop ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-gck N/A 1
PHENOTYPE
Data: 2 figures from O'Hare et al., 2016
Observed in:
DISEASE ASSOCIATED WITH gck HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial hyperinsulinemic hypoglycemia 3 Alliance Hyperinsulinemic hypoglycemia, familial, 3 602485
maturity-onset diabetes of the young type 2 Alliance MODY, type II 125851
permanent neonatal diabetes mellitus Alliance Diabetes mellitus, permanent neonatal 1 606176
type 2 diabetes mellitus Alliance Diabetes mellitus, noninsulin-dependent, late onset 125853
DISEASE ASSOCIATED WITH gck VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process endocrine pancreas development (more)
Cellular Component cytosol (more)
Molecular Function ATP binding (more)
GO Terms (all 23)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA gck-201 (1)    Ensembl 1427
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM gck No data available
MARKER RELATIONSHIPS
gck Contained in: [BAC] CH211-87L2 (1)
gck Encodes: [EST] fb57f10
[cDNA] MGC:153643 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001045385 (1) 1441 nt
Genomic GenBank:BX248505 (1) 189425 nt
Select Tool
Polypeptide UniProtKB:F1RC38 (1) 476 aa
Sequence Information (all 15)
ORTHOLOGY for gck ( Chr: 8 )
CITATIONS (57)