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General Information
ZIRC
ZFIN ID: ZDB-GENE-060825-1
Gene Name: cytochrome P450, family 24, subfamily A, polypeptide 1
Gene Symbol: cyp24a1    Nomenclature History

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Previous Name: cyp24a1l

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have heme binding activity; iron ion binding activity; and oxidoreductase activity. Predicted to be involved in oxidation-reduction process. Human ortholog(s) of this gene implicated in hypercalcemia. Is expressed in liver. Orthologous to human CYP24A1 (cytochrome P450 family 24 subfamily A member 1).
Genome Resources: Alliance (1),  Gene:100004700 (1),  Ensembl(GRCz11):ENSDARG00000103277 (1)
GENE EXPRESSION
All Expression Data: 8 figures from 5 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la025689Tg Transgenic Insertion Unknown Unknown DNA
la025690Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • pd272Tg Transgenic Insertion Unknown Unknown DNA_AND_TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    TALEN1-cyp24a1 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cyp24a1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Hypercalcemia, infantile, 1 143880
    DISEASE ASSOCIATED WITH cyp24a1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process oxidation-reduction process (more)
    Molecular Function heme binding (more)
    GO Terms (all 7)
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cyp24a1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(ubb:cyp24a1-2a-tagbfp) ubb 2Acyp24a1TagBFP Danio rerio 2 1
    MARKER RELATIONSHIPS
    cyp24a1 Encodes: [cDNA] MGC:158844 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001089458 (1)
    Genomic GenBank:FO704854 (1) 41583 bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IBW0 (1) 505 aa
    Sequence Clusters UniGene:87867 (1)
    Sequence Information (all 12)
    ORTHOLOGY for cyp24a1 ( Chr: 6 )
    CITATIONS (39)