ZFIN ID: ZDB-GENE-060824-6
Gene Name: wingless-type MMTV integration site family, member 2Bb
Gene Symbol: wnt2bb    Nomenclature History

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Previous Names: prometheus, prt

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have frizzled binding activity. Involved in several processes, including angiogenesis; hepaticobiliary system development; and swim bladder development. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in congenital diarrhea. Is expressed in several structures, including digestive system; heart; mesoderm; nervous system; and primordial vasculature. Orthologous to human WNT2B (Wnt family member 2B).
Genome Resources: Alliance (1),  Gene:556087 (1),  Ensembl(GRCz11):ENSDARG00000032234 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
s403 Point Mutation Unknown Missense ENU
s404 Point Mutation Unknown Premature Stop ENU
s416 Point Mutation Unknown Premature Stop ENU
sa34423 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34424 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • wnt2bb_unspecified Unspecified Unknown Unknown
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-wnt2bb N/A 4
    DISEASE ASSOCIATED WITH wnt2bb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Diarrhea 9 618168
    DISEASE ASSOCIATED WITH wnt2bb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angiogenesis (more)
    Cellular Component extracellular region (more)
    Molecular Function signaling receptor binding (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA wnt2bb-201 (1)    Ensembl 1413
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM wnt2bb
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:mCherry,wnt2bb) hsp70l mCherrywnt2bb Danio rerio 1 2
    Tg(hsp70l:mCherry,wnt2bb,cryaa:ECFP) cryaahsp70l ECFPmCherrywnt2bb Danio rerio 1 3
    MARKER RELATIONSHIPS
    wnt2bb Contained in: [BAC] DKEY-67N5 (1) (order this)
    wnt2bb Encodes: [cDNA] MGC:194365 (1), MGC:194374 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001044344 (1) 1413 nt
    Genomic GenBank:BX664731 (1) 104134 nt
    Select Tool
    Polypeptide UniProtKB:B0S7E3 (1) 396 aa
    Sequence Information (all 17)
    ORTHOLOGY for wnt2bb ( Chr: 8 )
    CITATIONS (52)