ZFIN ID: ZDB-GENE-060824-1
Gene Name: arrestin, beta 1
Gene Symbol: arrb1    Nomenclature History

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Previous Name: arrdc1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have G protein-coupled receptor binding activity. Involved in several processes, including endothelial to hematopoietic transition; regulation of microglial cell activation; and regulation of signal transduction. Predicted to localize to several cellular components, including cytoplasmic vesicle; cytosol; and nucleus. Is expressed in neural rod. Orthologous to human ARRB1 (arrestin beta 1).
Genome Resources: Alliance (1),  Gene:553266 (1),  Ensembl(GRCz11):ENSDARG00000043241 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Segmentation:5-9 somites (11.66h-14.0h) to Larval:Day 4 (96.0h-120.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa662 Point Mutation Unknown Premature Stop ENU
sa11194 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42478 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42479 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-arrb1 N/A 3
    MO2-arrb1 N/A 1
    MO3-arrb1 N/A 1
    DISEASE ASSOCIATED WITH arrb1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH arrb1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of Notch signaling pathway (more)
    Cellular Component cytoplasm (more)
    Molecular Function protein binding (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM arrb1 No data available
    MARKER RELATIONSHIPS No data available
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001159822 (1) 1257 nt
    Genomic GenBank:FO704791 (1) 93278 nt
    Select Tool
    Polypeptide UniProtKB:C3PTE8 (1) 418 aa
    Sequence Information (all 12)
    ORTHOLOGY for arrb1 ( Chr: 15 )
    CITATIONS (26)