Gene

bmp1a

ID
ZDB-GENE-060818-1
Name
bone morphogenetic protein 1a
Symbol
bmp1a Nomenclature History
Previous Names
  • frf
  • frilly fins
  • unm t31169
  • unm_t31169
  • wdd
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Exhibits peptidase activity. Involved in several processes, including collagen biosynthetic process; determination of ventral identity; and fin development. Used to study osteogenesis imperfecta and osteogenesis imperfecta type 13. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 13. Is expressed in several structures, including alar plate midbrain region; central nervous system; mesenchyme median fin fold; mesoderm; and optic vesicle. Orthologous to human BMP1 (bone morphogenetic protein 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
27 figures from 10 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With bmp1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
osteogenesis imperfecta type 13 Alliance Osteogenesis imperfecta, type XIII 614856
Associated With bmp1a Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR000859 CUB domain
Domain IPR001506 Peptidase M12A
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR006026 Peptidase, metallopeptidase
Domain IPR034036 Tolloid/BMP1 peptidase domain
Family IPR015446 Bone morphogenetic protein 1/tolloid-like protein
Family IPR029837 Bone morphogenetic protein 1
Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
Homologous_superfamily IPR035914 Spermadhesin, CUB domain superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Domain Details Per Protein
Protein Length Bone morphogenetic protein 1 Bone morphogenetic protein 1/tolloid-like protein CUB domain EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like domain EGF-type aspartate/asparagine hydroxylation site Metallopeptidase, catalytic domain superfamily Peptidase M12A Peptidase, metallopeptidase Spermadhesin, CUB domain superfamily Tolloid/BMP1 peptidase domain
UniProtKB:Q0NXS0 976
UniProtKB:F1REM3 976
UniProtKB:Q2ABP1 986
UniProtKB:A0A2R8QEK5 986
UniProtKB:B3DJM4 976
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations