ZFIN ID: ZDB-GENE-060818-1
Gene Name: bone morphogenetic protein 1a
Gene Symbol: bmp1a    Nomenclature History

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Previous Names: frf, frilly fins, unm t31169, unm_t31169, wdd

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Exhibits peptidase activity. Involved in several processes, including collagen biosynthetic process; determination of ventral identity; and fin development. Is expressed in several structures, including alar plate midbrain region; central nervous system; mesenchyme median fin fold; mesoderm; and optic vesicle. Used to study osteogenesis imperfecta and osteogenesis imperfecta type 13. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 13. Orthologous to human BMP1 (bone morphogenetic protein 1).
Genome Resources: Alliance (1),  Gene:572452 (1),  Ensembl(GRCz11):ENSDARG00000028071 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fr25 Point Mutation Unknown Missense ENU
sa2416 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa7161 Point Mutation Unknown Splice Site ENU
    sa12765 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17110 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34508 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • t31169 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tf5 Point Mutation Unknown Splice Site ENU
    th42 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm317a Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tp34 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tp207 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ty69 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tz252 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-bmp1a N/A 2
    MO2-bmp1a N/A 1
    MO3-bmp1a N/A 2
    MO4-bmp1a N/A 1
    MO5-bmp1a N/A 1
    DISEASE ASSOCIATED WITH bmp1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    osteogenesis imperfecta type 13 Alliance Osteogenesis imperfecta, type XIII 614856
    DISEASE ASSOCIATED WITH bmp1a VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    osteogenesis imperfecta type 13 bmp1asa2416/sa2416 standard conditions (2)
    osteogenesis imperfecta bmp1asa2416/sa2416 standard conditions Hur et al., 2017
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process proteolysis (more)
    Molecular Function peptidase activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM bmp1a No data available
    MARKER RELATIONSHIPS
    bmp1a Encodes: [cDNA] MGC:195055 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001040037 (1) 3212 nt
    Genomic GenBank:FQ859177 (1) 26932 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QEK5 (1) 986 aa
    Sequence Information (all 22)
    ORTHOLOGY for bmp1a ( Chr: 8 )
    CITATIONS (47)