ZFIN ID: ZDB-GENE-060810-94
Gene Name: lysine (K)-specific demethylase 5C
Gene Symbol: kdm5c    Nomenclature History

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Previous Names: im:7158173 (1), jarid1c (1), si:ch211-218o21.2, smcx (1), wu:fa28h03, wu:fi31b07

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have histone demethylase activity (H3-trimethyl-K4 specific). Involved in negative regulation of neuron apoptotic process. Predicted to localize to histone methyltransferase complex. Is expressed in brain; head; muscle; and spinal cord. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Claes-Jensen type. Orthologous to several human genes including KDM5C (lysine demethylase 5C).
Genome Resources: Alliance (1),  Gene:553406 (1),  Ensembl(GRCz11):ENSDARG00000006124 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7158173]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la026535Tg Transgenic Insertion Unknown Unknown DNA
la026536Tg Transgenic Insertion Unknown Unknown DNA
sa15146 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17413 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41261 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-kdm5c N/A 2
    MO2-kdm5c N/A 1
    MO3-kdm5c N/A 1
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH kdm5c HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    syndromic X-linked intellectual disability Claes-Jensen type Alliance Mental retardation, X-linked, syndromic, Claes-Jensen type 300534
    DISEASE ASSOCIATED WITH kdm5c VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of neuron apoptotic process (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kdm5c-201 (1)    Ensembl 6030
    ncRNA kdm5c-002 (1)    Ensembl 783
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kdm5c No data available
    MARKER RELATIONSHIPS
    kdm5c Contained in: [BAC] CH211-218O21 (1)
    kdm5c Encodes: [EST] fa28h03, fi31b07, IMAGE:7158173 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001123234 (1) 6030 nt
    Genomic GenBank:BX537348 (1) 207282 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B0S6L0 (1) 1578 aa
    Sequence Information (all 23)
    ORTHOLOGY for kdm5c ( Chr: 8 )
    CITATIONS (28)