Gene
wdr35
- ID
- ZDB-GENE-060810-148
- Name
- WD repeat domain 35
- Symbol
- wdr35 Nomenclature History
- Previous Names
-
- im:7159945 (1)
- si:ch211-206k20.4
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Acts upstream of or within cilium assembly. Predicted to be located in centrosome; ciliary basal body; and cytoplasm. Predicted to be part of intraciliary transport particle A. Predicted to be active in axoneme. Is expressed in head and post-vent region. Human ortholog(s) of this gene implicated in Ellis-Van Creveld syndrome; cranioectodermal dysplasia 2; and short-rib thoracic dysplasia 7 with or without polydactyly. Orthologous to human WDR35 (WD repeat domain 35).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7159945 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Stawicki et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cranioectodermal dysplasia 2 | Alliance | Cranioectodermal dysplasia 2 | 613610 |
| short-rib thoracic dysplasia 7 with or without polydactyly | Alliance | Short-rib thoracic dysplasia 7 with or without polydactyly | 614091 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR056157 | IFT80/172/WDR35, TPR domain |
| Domain | IPR056158 | WDR35, second beta-propeller domain |
| Domain | IPR056159 | WDR35/TULP4, N-terminal |
| Domain | IPR056170 | IFT121-like, zinc finger domain |
| Family | IPR017233 | WD repeat protein 35 |
| Family | IPR039857 | Intraflagellar transport protein 122/121 homolog |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | IFT121-like, zinc finger domain | IFT80/172/WDR35, TPR domain | Intraflagellar transport protein 122/121 homolog | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily | WDR35, second beta-propeller domain | WDR35/TULP4, N-terminal | WD repeat protein 35 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q9T9 | InterPro | 1184 | |||||||||
| UniProtKB:B7ZD88 | InterPro | 1203 |
Interactions and Pathways
No data available
Plasmids
No data available