| ZFIN ID: ZDB-GENE-060810-148 |
| Gene Name: | WD repeat domain 35 | |||||||||||||
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| Gene Symbol: | wdr35 Nomenclature History |
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Attributions
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| Previous Names: | im:7159945 (1), si:ch211-206k20.4 | |||||||||||||
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 13 Mapping Details/Browsers | |||||||||||||
| Description: | Involved in cilium assembly. Predicted to localize to the axoneme and intraciliary transport particle A. Human ortholog(s) of this gene implicated in Ellis-Van Creveld syndrome; Sensenbrenner syndrome; and short-rib thoracic dysplasia 7 with or without polydactyly. Orthologous to human WDR35 (WD repeat domain 35). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:565515 (1), Ensembl(GRCz11):ENSDARG00000069269 (2) | |||||||||||||
| Directly Submitted Expression Data: | 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7159945] |
| Wild-type Stages, Structures: | Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h) |
| Allele | Type | Localization | Consequence | Mutagen | Suppliers |
|---|---|---|---|---|---|
| sa14117 | Point Mutation | Unknown | Splice Site | ENU |
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| sa22338 | Point Mutation | Unknown | Splice Site | ENU |
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| sa35532 | Point Mutation | Unknown | Premature Stop | ENU |
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| sa42238 | Point Mutation | Unknown | Premature Stop | ENU |
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| w150 | Point Mutation | Unknown | Premature Stop | ENU |
| Data: | Fig. 5 from Stawicki et al., 2016 |
| Observed in: |
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Sensenbrenner syndrome | Alliance | Cranioectodermal dysplasia 2 | 613610 |
| short-rib thoracic dysplasia 7 with or without polydactyly | Alliance | Short-rib thoracic dysplasia 7 with or without polydactyly | 614091 |
| Ontology | GO Term |
|---|---|
| Biological Process | cilium assembly (more) |
| Cellular Component | cell projection (more) |
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| Type | Name | Length (nt) | Analysis | |
|---|---|---|---|---|
| aberrant processed transcript |
wdr35-203
(1)
|
800 |
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| mRNA |
wdr35-201
(1)
|
4088 |
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| ncRNA |
wdr35-003
(1)
|
584 |
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wdr35-004
(1)
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865 |
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| Browsers: UCSC, NCBI, Ensembl, ZFIN |
| wdr35 Contained in: | [BAC] CH211-206K20 (1) (order this) |
| wdr35 Encodes: | [EST] IMAGE:7159945 (1) (order this) |
| Type | Accession # | Length (bp/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:NM_001145589 (1) |
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| Genomic | GenBank:AL935163 (1) | 158350 bp | |
| Polypeptide | UniProtKB:B7ZD88 (1) | 1203 aa |
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| Sequence Clusters | UniGene:87936 (1) |
