Gene

wdr35

ID

ZDB-GENE-060810-148

Name

WD repeat domain 35

Symbol

wdr35 Nomenclature History

Previous Names

im:7159945 (1)
si:ch211-206k20.4

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Acts upstream of or within cilium assembly. Predicted to be located in ciliary basal body and cytoplasm. Predicted to be part of intraciliary transport particle A. Predicted to be active in axoneme. Is expressed in head and post-vent region. Human ortholog(s) of this gene implicated in Ellis-Van Creveld syndrome; cranioectodermal dysplasia 2; and short-rib thoracic dysplasia 7 with or without polydactyly. Orthologous to human WDR35 (WD repeat domain 35).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7159945 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Stawicki et al., 2016
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With wdr35 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cranioectodermal dysplasia 2	Alliance	Cranioectodermal dysplasia 2	613610
short-rib thoracic dysplasia 7 with or without polydactyly	Alliance	Short-rib thoracic dysplasia 7 with or without polydactyly	614091

Associated With wdr35 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR017233	WD repeat protein 35
Family	IPR039857	Intraflagellar transport protein 122/121 homolog
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat

Domain Details Per Protein

Protein	Length	Intraflagellar transport protein 122/121 homolog	WD40 repeat	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily	WD repeat protein 35
UniProtKB:A0A8M9Q9T9 InterPro	1184
UniProtKB:B7ZD88 InterPro	1203

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
aberrant processed transcript	wdr35-203 (1) Ensembl	800 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	wdr35-201 (1) Ensembl	4088 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	wdr35-003 (1) Ensembl	584 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	wdr35-004 (1) Ensembl	865 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations