ZFIN ID: ZDB-GENE-060626-1
Gene Name: DNA topoisomerase II binding protein 1
Gene Symbol: topbp1    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Involved in cellular response to DNA damage stimulus; definitive hemopoiesis; and regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Localizes to the nucleus. Is expressed in caudal fin and head. Orthologous to human TOPBP1 (DNA topoisomerase II binding protein 1).
Genome Resources: Alliance (1),  Gene:407679 (1),  Ensembl(GRCz11):ENSDARG00000059322 (2)
GENE EXPRESSION
All Expression Data: Fig. S5 from Gao et al., 2015
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
cas003 Point Mutation Unknown Premature Stop ENU
  • China Zebrafish Resource Center (CZRC) (order this)
  • sa16043 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-topbp1
    1
    MO1-topbp1 N/A 1
    MO2-topbp1 N/A 1
    DISEASE ASSOCIATED WITH topbp1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH topbp1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to DNA damage stimulus (more)
    Cellular Component nucleus (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001357 BRCT domain
    Homologous_superfamily IPR036420 BRCT domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA topbp1-202 (1)    Ensembl 4697
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM topbp1 No data available
    MARKER RELATIONSHIPS
    topbp1 Contained in: [BAC] DKEY-81F9 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001199738 (1)
    Genomic GenBank:BX649325 (1) 169135 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8RVN3 (1) 1526 aa
    Sequence Information (all 15)
    ORTHOLOGY for topbp1 ( Chr: 24 )
    CITATIONS (18)