ZFIN is now using GRCz12tu for Genomic Data
Gene
tlk2
- ID
- ZDB-GENE-060623-36
- Name
- tousled-like kinase 2
- Symbol
- tlk2 Nomenclature History
- Previous Names
-
- wu:fi16h09
- wu:fi30g12
- zgc:136697
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in chromosome segregation and intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in cytoplasm; cytoskeleton; and nucleoplasm. Predicted to be active in nucleus and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human TLK2 (tousled like kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 57 | Alliance | Intellectual developmental disorder, autosomal dominant 57 | 618050 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8QUZ6 | InterPro | 697 | ||||
| UniProtKB:A0A8M9PXE3 | InterPro | 696 | ||||
| UniProtKB:Q1ECX4 | InterPro | 697 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers