ZFIN ID: ZDB-GENE-060616-396
Gene Name: neuronal PAS domain protein 4a
Gene Symbol: npas4a    Nomenclature History

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Previous Names: npas4, wu:fj52d04, zgc:136764

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in blood vessel development and forebrain development. Predicted to localize to the nucleus. Is expressed in forebrain. Orthologous to human NPAS4 (neuronal PAS domain protein 4).
Genome Resources: Alliance (1),  Gene:724016 (1),  Ensembl(GRCz11):ENSDARG00000055752 (2)
GENE EXPRESSION
All Expression Data: 5 figures from 3 publications
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa701 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16063 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-npas4a N/A 1
    MO2-npas4a N/A 1
    PHENOTYPE
    Data: Fig. 7 from Klarić et al., 2014
    Observed in:
    DISEASE ASSOCIATED WITH npas4a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH npas4a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process blood vessel development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000014 PAS domain
    Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    Domain IPR013655 PAS fold-3
    Homologous_superfamily IPR035965 PAS domain superfamily
    Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA npas4a-201 (1)    Ensembl 4736
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM npas4a No data available
    MARKER RELATIONSHIPS
    npas4a Contained in: [BAC] CH73-31A8 (1)
    npas4a Encodes: [EST] fj52d04
    [cDNA] MGC:136764 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001045321 (1) 4768 bp
    Genomic GenBank:BX323810 (1) 166625 bp
    Select Tool
    Polypeptide UniProtKB:Q1ECW2 (1) 933 aa
    Sequence Clusters UniGene:81110 (1)
    Sequence Information (all 15)
    ORTHOLOGY for npas4a ( Chr: 14 )
    CITATIONS (38)