Gene
npas4a
- ID
- ZDB-GENE-060616-396
- Name
- neuronal PAS domain protein 4a
- Symbol
- npas4a Nomenclature History
- Previous Names
-
- npas4
- wu:fj52d04
- zgc:136764
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within blood vessel development and forebrain development. Predicted to be located in nucleus. Is expressed in forebrain. Orthologous to human NPAS4 (neuronal PAS domain protein 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Klari? et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-npas4a | N/A | Klarić et al., 2014 |
| MO2-npas4a | N/A | Esser et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Myc-type, basic helix-loop-helix (bHLH) domain | PAS domain | PAS domain superfamily |
|---|---|---|---|---|---|
| UniProtKB:Q1ECW2 | InterPro | 933 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
npas4a-201
(1)
|
Ensembl | 4,736 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-31A8 | ZFIN Curated Data | |
| Encodes | EST | fj52d04 | ||
| Encodes | cDNA | MGC:136764 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045321 (1) | 4768 nt | ||
| Genomic | GenBank:BX323810 (1) | 166625 nt | ||
| Polypeptide | UniProtKB:Q1ECW2 (1) | 933 aa |
- Gawel, K., Hulas-Stasiak, M., Marszalek-Grabska, M., Grenda, A., Siekierska, A., Kosheva, N., van der Ent, W., Esguerra, C.V., Krawczyk, P., Turski, W.A. (2024) Induction of seizures and initiation of epileptogenesis by pilocarpine in zebrafish larvae. Frontiers in molecular neuroscience. 17:14186061418606
- Sui, J., Zhan, L., Ji, S., Wu, W., Chen, Y., Yun, F., Liang, W., Wang, J., Cao, M., Shen, D., Zhang, Q. (2024) Differential inflammation responses determine the variable phenotypes of epilepsy induced by GABRG2 mutations. CNS neuroscience & therapeutics. 30:e14583e14583
- Eachus, H., Oberski, L., Paveley, J., Bacila, I., Ashton, J.P., Esposito, U., Seifuddin, F., Pirooznia, M., Elhaik, E., Placzek, M., Krone, N., Cunliffe, V.T. (2023) Glucocorticoid Receptor regulates protein chaperone, circadian clock and affective disorder genes in the zebrafish brain. Disease models & mechanisms. 16(9):
- Hu, H., Long, Y., Song, G., Chen, S., Xu, Z., Li, Q., Wu, Z. (2023) Dysfunction of Prkcaa Links Social Behavior Defects with Disturbed Circadian Rhythm in Zebrafish. International Journal of Molecular Sciences. 24(4):
- Kareklas, K., Teles, M.C., Dreosti, E., Oliveira, R.F. (2023) Autism-associated gene shank3 is necessary for social contagion in zebrafish. Molecular autism. 14:2323
- Chen, H., Siu, S.W.I., Wong, C.T.T., Qiu, J., Cheung, A.K., Lee, S.M.Y. (2022) Anti-epileptic Kunitz-like peptides discovered in the branching coral Acropora digitifera through transcriptomic analysis. Archives of toxicology. 96(9):2589-2608
- Osorio-Méndez, D., Miller, A., Begeman, I.J., Kurth, A., Hagle, R., Rolph, D., Dickson, A.L., Chen, C.H., Halloran, M., Poss, K.D., Kang, J. (2022) Voltage-gated sodium channel scn8a is required for innervation and regeneration of amputated adult zebrafish fins. Proceedings of the National Academy of Sciences of the United States of America. 119:e2200342119
- Wilson, P.W., Cho, C., Allsing, N., Khanum, S., Bose, P., Grubschmidt, A., Sant, K.E. (2022) Tris(4-chlorophenyl)methane and tris(4-chlorophenyl)methanol disrupt pancreatic organogenesis and gene expression in zebrafish embryos. Birth defects research. 115(4):458-473
- Baker, M.R., Wong, R.Y. (2021) Npas4a expression in the teleost forebrain is associated with stress coping style differences in fear learning. Scientific Reports. 11:12074
- Kuretani, A., Yamamoto, T., Taira, M., Michiue, T. (2021) Evolution of hes gene family in vertebrates: the hes5 cluster genes have specifically increased in frogs. BMC ecology and evolution. 21:147
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